The prognostic significance of trisomy 8 in patients with acute myeloid leukemia

Michelle A. Elliott, Louis Letendre, Curtis A. Hanson, Ayalew Tefferi, Gordon W. Dewald

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Recent therapeutic outcomes for patients with acute myeloid leukemia and trisomy 8 (+8) who were seen at our institution were investigated. Complete remission was achieved in 85% with isolated +8, 100% with +8 and chromosomal abnormalities predictive of a favorable outcome, and 47% of patients with +8 and other, mostly complex chromosomal abnormalities. Median relapse-free and overall survivals in months were 5.5 and 12 (isolated +8), 20 and 25 (+8 and favorable karyotype), and 7.5 and 6 (+8 and unfavorable karyotype). Despite an encouraging rate of complete remission, the relapse-free and overall survivals for patients with isolated +8 were not significantly different from those of patients with +8 and unfavorable karyotypes. The presence of +8 did not appear to adversely affect the outcome of patients with favorable karyotypes.

Original languageEnglish (US)
Pages (from-to)583-586
Number of pages4
JournalLeukemia and Lymphoma
Volume43
Issue number3
DOIs
StatePublished - Mar 27 2002

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Keywords

  • Leukemia
  • Myeloid
  • Treatment outcome
  • Trisomy 8

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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