Abstract
Recent therapeutic outcomes for patients with acute myeloid leukemia and trisomy 8 (+8) who were seen at our institution were investigated. Complete remission was achieved in 85% with isolated +8, 100% with +8 and chromosomal abnormalities predictive of a favorable outcome, and 47% of patients with +8 and other, mostly complex chromosomal abnormalities. Median relapse-free and overall survivals in months were 5.5 and 12 (isolated +8), 20 and 25 (+8 and favorable karyotype), and 7.5 and 6 (+8 and unfavorable karyotype). Despite an encouraging rate of complete remission, the relapse-free and overall survivals for patients with isolated +8 were not significantly different from those of patients with +8 and unfavorable karyotypes. The presence of +8 did not appear to adversely affect the outcome of patients with favorable karyotypes.
Original language | English (US) |
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Pages (from-to) | 583-586 |
Number of pages | 4 |
Journal | Leukemia and Lymphoma |
Volume | 43 |
Issue number | 3 |
DOIs | |
State | Published - 2002 |
Keywords
- Leukemia
- Myeloid
- Treatment outcome
- Trisomy 8
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research