The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors

J. Matthew McDonald, Siew Ju See, Ivo W. Tremont, Howard Colman, Mark R. Gilbert, Morris Groves, Peter C. Burger, David N. Louis, Caterina Giannini, Gregory Fuller, Sandra Passe, Hilary Blair, Robert B. Jenkins, Helen Yang, Alicia Ledoux, Joann Aaron, Ulka Tipnis, Wei Zhang, Kenneth Hess, Ken Aldape

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86 Scopus citations

Abstract

BACKGROUND. It has been reported previously that the combined loss of chromosomal arms 1p and 19q is a significant predictor of outcome for patients with anaplastic oligodendroglial (AO) tumors and that such chromosomal loss correlates with classic histology in AO. The authors sought to determine whether histology was an equivalent or superior predictor of outcome compared with 1p/19q status in 131 patients with AO tumors. METHODS. The status of 1p and 19q was determined using real-time, quantitative polymerase chain reaction analysis and/or fluorescence in situ hybridization. Clinical features (response to adjuvant therapy and tumor location) and molecular genetic abnormalities (9p and 10q deletions, overexpression of p53 and epidermal growth factor receptor) were determined on available specimens. Histologic assessments for classic oligodendroglial features were performed by five neuropathologists. RESULTS. Classic histology was associated closely with 1p/19q loss, as reported previously. Patients who had tumors that were considered classic by at least four of the five neuropathologists showed significantly increased progression-free and overall survival compared with the patients who had less classic tumors. The authors also tested the correlation between 1p/19q status and outcome in subsets of patients stratified according to classic tumor features. The association of 1p/19q status with survival was related closely to the presence of classic histology. Loss of 1p/19q was predictive of improved outcome only among patients who had tumors with classic histologic features. CONCLUSIONS. The current results suggested that, in addition to 1p/19q status, histologic features contribute information to the prediction of outcome in patients with AO. Loss of 1p and 19q appeared to be a prognostic marker only in the subset of patients who had AO tumors with classic histologic features.

Original languageEnglish (US)
Pages (from-to)1468-1477
Number of pages10
JournalCancer
Volume104
Issue number7
DOIs
StatePublished - Oct 1 2005

Keywords

  • 1p/19q status
  • Monomorphic pattern
  • Nonrandom allelic loss
  • Oligodendroglioma
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    McDonald, J. M., See, S. J., Tremont, I. W., Colman, H., Gilbert, M. R., Groves, M., Burger, P. C., Louis, D. N., Giannini, C., Fuller, G., Passe, S., Blair, H., Jenkins, R. B., Yang, H., Ledoux, A., Aaron, J., Tipnis, U., Zhang, W., Hess, K., & Aldape, K. (2005). The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors. Cancer, 104(7), 1468-1477. https://doi.org/10.1002/cncr.21338