The PRKD1 promoter is a target of the KRas-NF-κ B pathway in pancreatic cancer

Heike Döppler, Richard Panayiotou, Elizabeth M. Reid, Willibroad Maimo, Ligia Bastea, Peter Storz

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Increased expression of PRKD1 and its gene product protein kinase D1 (PKD1) are linked to oncogenic signaling in pancreatic ductal adenocarcinoma, but a direct functional relationship to oncogenic KRas has not been established so far. We here describe the PRKD1 gene promoter as a target for oncogenic KRas signaling. We demonstrate that KRas-induced activation of the canonical NF-κ B pathway is one mechanism of how PRKD1 expression is increased and identify the binding sites for NF-κ B in the PRKD1 promoter. Altogether, these results describe a novel mechanism governing PRKD1 gene expression in PDA and provide a functional link between oncogenic KRas, NF-κ B and expression of PRKD1.

Original languageEnglish (US)
Article number33758
JournalScientific Reports
StatePublished - Sep 21 2016


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