The PRKD1 promoter is a target of the KRas-NF-κ B pathway in pancreatic cancer

Heike Döppler, Richard Panayiotou, Elizabeth M. Reid, Willibroad Maimo, Ligia Bastea, Peter Storz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Increased expression of PRKD1 and its gene product protein kinase D1 (PKD1) are linked to oncogenic signaling in pancreatic ductal adenocarcinoma, but a direct functional relationship to oncogenic KRas has not been established so far. We here describe the PRKD1 gene promoter as a target for oncogenic KRas signaling. We demonstrate that KRas-induced activation of the canonical NF-κ B pathway is one mechanism of how PRKD1 expression is increased and identify the binding sites for NF-κ B in the PRKD1 promoter. Altogether, these results describe a novel mechanism governing PRKD1 gene expression in PDA and provide a functional link between oncogenic KRas, NF-κ B and expression of PRKD1.

Original languageEnglish (US)
Article number33758
JournalScientific Reports
Volume6
DOIs
StatePublished - Sep 21 2016

Fingerprint

Pancreatic Neoplasms
Protein Kinases
Genes
Adenocarcinoma
Binding Sites
Gene Expression

ASJC Scopus subject areas

  • General

Cite this

The PRKD1 promoter is a target of the KRas-NF-κ B pathway in pancreatic cancer. / Döppler, Heike; Panayiotou, Richard; Reid, Elizabeth M.; Maimo, Willibroad; Bastea, Ligia; Storz, Peter.

In: Scientific Reports, Vol. 6, 33758, 21.09.2016.

Research output: Contribution to journalArticle

Döppler, Heike ; Panayiotou, Richard ; Reid, Elizabeth M. ; Maimo, Willibroad ; Bastea, Ligia ; Storz, Peter. / The PRKD1 promoter is a target of the KRas-NF-κ B pathway in pancreatic cancer. In: Scientific Reports. 2016 ; Vol. 6.
@article{9c5c35af11ca4f8f82cbda5075ab67da,
title = "The PRKD1 promoter is a target of the KRas-NF-κ B pathway in pancreatic cancer",
abstract = "Increased expression of PRKD1 and its gene product protein kinase D1 (PKD1) are linked to oncogenic signaling in pancreatic ductal adenocarcinoma, but a direct functional relationship to oncogenic KRas has not been established so far. We here describe the PRKD1 gene promoter as a target for oncogenic KRas signaling. We demonstrate that KRas-induced activation of the canonical NF-κ B pathway is one mechanism of how PRKD1 expression is increased and identify the binding sites for NF-κ B in the PRKD1 promoter. Altogether, these results describe a novel mechanism governing PRKD1 gene expression in PDA and provide a functional link between oncogenic KRas, NF-κ B and expression of PRKD1.",
author = "Heike D{\"o}ppler and Richard Panayiotou and Reid, {Elizabeth M.} and Willibroad Maimo and Ligia Bastea and Peter Storz",
year = "2016",
month = "9",
day = "21",
doi = "10.1038/srep33758",
language = "English (US)",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - The PRKD1 promoter is a target of the KRas-NF-κ B pathway in pancreatic cancer

AU - Döppler, Heike

AU - Panayiotou, Richard

AU - Reid, Elizabeth M.

AU - Maimo, Willibroad

AU - Bastea, Ligia

AU - Storz, Peter

PY - 2016/9/21

Y1 - 2016/9/21

N2 - Increased expression of PRKD1 and its gene product protein kinase D1 (PKD1) are linked to oncogenic signaling in pancreatic ductal adenocarcinoma, but a direct functional relationship to oncogenic KRas has not been established so far. We here describe the PRKD1 gene promoter as a target for oncogenic KRas signaling. We demonstrate that KRas-induced activation of the canonical NF-κ B pathway is one mechanism of how PRKD1 expression is increased and identify the binding sites for NF-κ B in the PRKD1 promoter. Altogether, these results describe a novel mechanism governing PRKD1 gene expression in PDA and provide a functional link between oncogenic KRas, NF-κ B and expression of PRKD1.

AB - Increased expression of PRKD1 and its gene product protein kinase D1 (PKD1) are linked to oncogenic signaling in pancreatic ductal adenocarcinoma, but a direct functional relationship to oncogenic KRas has not been established so far. We here describe the PRKD1 gene promoter as a target for oncogenic KRas signaling. We demonstrate that KRas-induced activation of the canonical NF-κ B pathway is one mechanism of how PRKD1 expression is increased and identify the binding sites for NF-κ B in the PRKD1 promoter. Altogether, these results describe a novel mechanism governing PRKD1 gene expression in PDA and provide a functional link between oncogenic KRas, NF-κ B and expression of PRKD1.

UR - http://www.scopus.com/inward/record.url?scp=84988807099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988807099&partnerID=8YFLogxK

U2 - 10.1038/srep33758

DO - 10.1038/srep33758

M3 - Article

C2 - 27649783

AN - SCOPUS:84988807099

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 33758

ER -