The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease

on behalf of the PRIAMO study group

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages. Methods: A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). Results: As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Conclusions: Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.

Original languageEnglish (US)
JournalJournal of Neurology
DOIs
StateAccepted/In press - 2020

Keywords

  • Constipation
  • Heterogeneity
  • Parkinson
  • Phenotype
  • Prodromal
  • Sex

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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