The prevalence of diabetic cardiomyopathy: A population-based study in Olmsted County, Minnesota

Sanjay Dandamudi, Joshua Slusser, Douglas W. Mahoney, Margaret May Redfield, Richard J. Rodeheffer, Horng Haur Chen

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Background Diabetic cardiomyopathy defined as either systolic or diastolic dysfunction in otherwise healthy diabetic persons is not clearly understood. The prevalence and outcomes of this disease in a community-based population have not been defined. Methods and Results Cross-sectional survey of 2042 randomly selected residents of Olmsted County, Minnesota, aged 45 years or older between June 1997 and September 2000. All patients underwent Doppler echocardiographic assessment of systolic and diastolic function. Diabetic cardiomyopathy was defined in a person with diabetes and any systolic or at least moderate diastolic dysfunction without a history of coronary disease, hypertension, significant valvular disease, or congenital heart disease. The diagnosis of diabetic cardiomyopathy was made in 23 people, corresponding to a community population prevalence rate of 1.1%. Among diabetic patients, 16.9% met criteria for diabetic cardiomyopathy and 54.4% had diastolic dysfunction. Diabetes was associated with a 1.9-fold increase in risk of any left ventricular dysfunction, a 1.7-fold increase in risk of diastolic dysfunction, and a 2.2-fold increase in risk of systolic dysfunction. Among patients with diabetic cardiomyopathy, the cumulative probability of death was 18%, development of heart failure was 22%, and development of death or heart failure was 31% at 9 years. Conclusion Diabetic cardiomyopathy is relatively common in the community with a prevalence of 1.1%. The morbidity and mortality of patients with diabetic cardiomyopathy is high.

Original languageEnglish (US)
Pages (from-to)304-309
Number of pages6
JournalJournal of Cardiac Failure
Volume20
Issue number5
DOIs
StatePublished - 2014

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Diabetic Cardiomyopathies
Population
Heart Failure
Left Ventricular Dysfunction
Coronary Disease
Heart Diseases
Cross-Sectional Studies
Hypertension
Morbidity
Mortality

Keywords

  • Diabetes mellitus
  • diabetic cardiomyopathy
  • heart failure
  • left ventricular dysfunction
  • Olmsted County
  • prevalence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The prevalence of diabetic cardiomyopathy : A population-based study in Olmsted County, Minnesota. / Dandamudi, Sanjay; Slusser, Joshua; Mahoney, Douglas W.; Redfield, Margaret May; Rodeheffer, Richard J.; Chen, Horng Haur.

In: Journal of Cardiac Failure, Vol. 20, No. 5, 2014, p. 304-309.

Research output: Contribution to journalArticle

Dandamudi, Sanjay ; Slusser, Joshua ; Mahoney, Douglas W. ; Redfield, Margaret May ; Rodeheffer, Richard J. ; Chen, Horng Haur. / The prevalence of diabetic cardiomyopathy : A population-based study in Olmsted County, Minnesota. In: Journal of Cardiac Failure. 2014 ; Vol. 20, No. 5. pp. 304-309.
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abstract = "Background Diabetic cardiomyopathy defined as either systolic or diastolic dysfunction in otherwise healthy diabetic persons is not clearly understood. The prevalence and outcomes of this disease in a community-based population have not been defined. Methods and Results Cross-sectional survey of 2042 randomly selected residents of Olmsted County, Minnesota, aged 45 years or older between June 1997 and September 2000. All patients underwent Doppler echocardiographic assessment of systolic and diastolic function. Diabetic cardiomyopathy was defined in a person with diabetes and any systolic or at least moderate diastolic dysfunction without a history of coronary disease, hypertension, significant valvular disease, or congenital heart disease. The diagnosis of diabetic cardiomyopathy was made in 23 people, corresponding to a community population prevalence rate of 1.1{\%}. Among diabetic patients, 16.9{\%} met criteria for diabetic cardiomyopathy and 54.4{\%} had diastolic dysfunction. Diabetes was associated with a 1.9-fold increase in risk of any left ventricular dysfunction, a 1.7-fold increase in risk of diastolic dysfunction, and a 2.2-fold increase in risk of systolic dysfunction. Among patients with diabetic cardiomyopathy, the cumulative probability of death was 18{\%}, development of heart failure was 22{\%}, and development of death or heart failure was 31{\%} at 9 years. Conclusion Diabetic cardiomyopathy is relatively common in the community with a prevalence of 1.1{\%}. The morbidity and mortality of patients with diabetic cardiomyopathy is high.",
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N2 - Background Diabetic cardiomyopathy defined as either systolic or diastolic dysfunction in otherwise healthy diabetic persons is not clearly understood. The prevalence and outcomes of this disease in a community-based population have not been defined. Methods and Results Cross-sectional survey of 2042 randomly selected residents of Olmsted County, Minnesota, aged 45 years or older between June 1997 and September 2000. All patients underwent Doppler echocardiographic assessment of systolic and diastolic function. Diabetic cardiomyopathy was defined in a person with diabetes and any systolic or at least moderate diastolic dysfunction without a history of coronary disease, hypertension, significant valvular disease, or congenital heart disease. The diagnosis of diabetic cardiomyopathy was made in 23 people, corresponding to a community population prevalence rate of 1.1%. Among diabetic patients, 16.9% met criteria for diabetic cardiomyopathy and 54.4% had diastolic dysfunction. Diabetes was associated with a 1.9-fold increase in risk of any left ventricular dysfunction, a 1.7-fold increase in risk of diastolic dysfunction, and a 2.2-fold increase in risk of systolic dysfunction. Among patients with diabetic cardiomyopathy, the cumulative probability of death was 18%, development of heart failure was 22%, and development of death or heart failure was 31% at 9 years. Conclusion Diabetic cardiomyopathy is relatively common in the community with a prevalence of 1.1%. The morbidity and mortality of patients with diabetic cardiomyopathy is high.

AB - Background Diabetic cardiomyopathy defined as either systolic or diastolic dysfunction in otherwise healthy diabetic persons is not clearly understood. The prevalence and outcomes of this disease in a community-based population have not been defined. Methods and Results Cross-sectional survey of 2042 randomly selected residents of Olmsted County, Minnesota, aged 45 years or older between June 1997 and September 2000. All patients underwent Doppler echocardiographic assessment of systolic and diastolic function. Diabetic cardiomyopathy was defined in a person with diabetes and any systolic or at least moderate diastolic dysfunction without a history of coronary disease, hypertension, significant valvular disease, or congenital heart disease. The diagnosis of diabetic cardiomyopathy was made in 23 people, corresponding to a community population prevalence rate of 1.1%. Among diabetic patients, 16.9% met criteria for diabetic cardiomyopathy and 54.4% had diastolic dysfunction. Diabetes was associated with a 1.9-fold increase in risk of any left ventricular dysfunction, a 1.7-fold increase in risk of diastolic dysfunction, and a 2.2-fold increase in risk of systolic dysfunction. Among patients with diabetic cardiomyopathy, the cumulative probability of death was 18%, development of heart failure was 22%, and development of death or heart failure was 31% at 9 years. Conclusion Diabetic cardiomyopathy is relatively common in the community with a prevalence of 1.1%. The morbidity and mortality of patients with diabetic cardiomyopathy is high.

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