The prevalence and significance of Staphylococcus aureus in patients with non-cystic fibrosis bronchiectasis

Mark L. Metersky, Timothy Aksamit, Alan Barker, Radmila Choate, Charles L. Daley, Leigh A. Daniels, Angela DiMango, Edward Eden, David Griffith, Margaret Johnson, Michael Knowles, Anne E. O'Donnell, Kenneth Olivier, Matthias Salathe, Byron Thomashow, Gregory Tino, Gerard Turino, Kevin L. Winthrop, David Mannino

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Rationale: Staphylococcus aureus is commonly cultured from the sputum of patients with bronchiectasis; however, little is known about the prevalence of the organism in these patients, the characteristics of patients who have grown the organism, or its implications. Objectives: Determine the relationship between S. aureus and pulmonary function, frequency of exacerbations, and frequency of hospitalization in patients with bronchiectasis Methods:TheBronchiectasisResearchRegistry is a database of adults with non-cystic fibrosis bronchiectasis identified from 13 sites within the United States. Baseline and follow-up demographic, spirometric, microbiologic, and therapeutic data were entered into a central webbased database. Patientswere grouped into three cohorts based on their previous respiratory cultures at the time of entry into theRegistry: 1) no prior S. aureus or glucose-nonfermenting gram-negative bacilli (NFGNB) (Pseudomonas, Stenotrophomonas, or Burkholderia spp.); 2) prior S. aureus at least once; or 3) no prior S. aureus but prior NF-GNB at least once. The association between S. aureus isolation and pulmonary function and frequency of exacerbations and hospital admissions was assessed, both at baseline and after 1 year of follow-up. Results: S. aureus was cultured from 94 of 830 patients (11.3%) included in the analysis. Patients who had grown S. aureus before entry into the Registry had a frequency of prior exacerbations and baseline pulmonary function that was between that of patients who had grown NF-GNB and those who had grown neither NF-GNB or S. aureus. Similarly, at the first follow-up visit after study entry, patients who had grown S. aureus had a frequency of exacerbations and hospitalizations that was between those of patients who had grown NF-GNB and those who had grown neither NF-GNB nor S. aureus. However, in multivariate analysis, S. aureus was not associated with pulmonary function, frequency of exacerbation, or hospital admissions. There were no significant differences in patient characteristics or outcomes between patients who had methicillin-sensitive and methicillin-resistant S. aureus. Conclusions: Staphylococcus aureus does not appear to be an independent risk factor for severe disease in patients with bronchiectasis enrolled in the Bronchiectasis Research Registry.

Original languageEnglish (US)
Pages (from-to)365-370
Number of pages6
JournalAnnals of the American Thoracic Society
Volume15
Issue number3
DOIs
StatePublished - Mar 1 2018

Fingerprint

Bronchiectasis
Staphylococcus aureus
Fibrosis
Lung
Registries
Hospitalization
Stenotrophomonas
Databases
Burkholderia
Methicillin
Methicillin-Resistant Staphylococcus aureus
Pseudomonas
Sputum
Bacillus
Multivariate Analysis

Keywords

  • Bronchiectasis
  • Methicillinresistant Staphylococcus aureus
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

The prevalence and significance of Staphylococcus aureus in patients with non-cystic fibrosis bronchiectasis. / Metersky, Mark L.; Aksamit, Timothy; Barker, Alan; Choate, Radmila; Daley, Charles L.; Daniels, Leigh A.; DiMango, Angela; Eden, Edward; Griffith, David; Johnson, Margaret; Knowles, Michael; O'Donnell, Anne E.; Olivier, Kenneth; Salathe, Matthias; Thomashow, Byron; Tino, Gregory; Turino, Gerard; Winthrop, Kevin L.; Mannino, David.

In: Annals of the American Thoracic Society, Vol. 15, No. 3, 01.03.2018, p. 365-370.

Research output: Contribution to journalArticle

Metersky, ML, Aksamit, T, Barker, A, Choate, R, Daley, CL, Daniels, LA, DiMango, A, Eden, E, Griffith, D, Johnson, M, Knowles, M, O'Donnell, AE, Olivier, K, Salathe, M, Thomashow, B, Tino, G, Turino, G, Winthrop, KL & Mannino, D 2018, 'The prevalence and significance of Staphylococcus aureus in patients with non-cystic fibrosis bronchiectasis', Annals of the American Thoracic Society, vol. 15, no. 3, pp. 365-370. https://doi.org/10.1513/AnnalsATS.201706-426OC
Metersky, Mark L. ; Aksamit, Timothy ; Barker, Alan ; Choate, Radmila ; Daley, Charles L. ; Daniels, Leigh A. ; DiMango, Angela ; Eden, Edward ; Griffith, David ; Johnson, Margaret ; Knowles, Michael ; O'Donnell, Anne E. ; Olivier, Kenneth ; Salathe, Matthias ; Thomashow, Byron ; Tino, Gregory ; Turino, Gerard ; Winthrop, Kevin L. ; Mannino, David. / The prevalence and significance of Staphylococcus aureus in patients with non-cystic fibrosis bronchiectasis. In: Annals of the American Thoracic Society. 2018 ; Vol. 15, No. 3. pp. 365-370.
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abstract = "Rationale: Staphylococcus aureus is commonly cultured from the sputum of patients with bronchiectasis; however, little is known about the prevalence of the organism in these patients, the characteristics of patients who have grown the organism, or its implications. Objectives: Determine the relationship between S. aureus and pulmonary function, frequency of exacerbations, and frequency of hospitalization in patients with bronchiectasis Methods:TheBronchiectasisResearchRegistry is a database of adults with non-cystic fibrosis bronchiectasis identified from 13 sites within the United States. Baseline and follow-up demographic, spirometric, microbiologic, and therapeutic data were entered into a central webbased database. Patientswere grouped into three cohorts based on their previous respiratory cultures at the time of entry into theRegistry: 1) no prior S. aureus or glucose-nonfermenting gram-negative bacilli (NFGNB) (Pseudomonas, Stenotrophomonas, or Burkholderia spp.); 2) prior S. aureus at least once; or 3) no prior S. aureus but prior NF-GNB at least once. The association between S. aureus isolation and pulmonary function and frequency of exacerbations and hospital admissions was assessed, both at baseline and after 1 year of follow-up. Results: S. aureus was cultured from 94 of 830 patients (11.3{\%}) included in the analysis. Patients who had grown S. aureus before entry into the Registry had a frequency of prior exacerbations and baseline pulmonary function that was between that of patients who had grown NF-GNB and those who had grown neither NF-GNB or S. aureus. Similarly, at the first follow-up visit after study entry, patients who had grown S. aureus had a frequency of exacerbations and hospitalizations that was between those of patients who had grown NF-GNB and those who had grown neither NF-GNB nor S. aureus. However, in multivariate analysis, S. aureus was not associated with pulmonary function, frequency of exacerbation, or hospital admissions. There were no significant differences in patient characteristics or outcomes between patients who had methicillin-sensitive and methicillin-resistant S. aureus. Conclusions: Staphylococcus aureus does not appear to be an independent risk factor for severe disease in patients with bronchiectasis enrolled in the Bronchiectasis Research Registry.",
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AU - Aksamit, Timothy

AU - Barker, Alan

AU - Choate, Radmila

AU - Daley, Charles L.

AU - Daniels, Leigh A.

AU - DiMango, Angela

AU - Eden, Edward

AU - Griffith, David

AU - Johnson, Margaret

AU - Knowles, Michael

AU - O'Donnell, Anne E.

AU - Olivier, Kenneth

AU - Salathe, Matthias

AU - Thomashow, Byron

AU - Tino, Gregory

AU - Turino, Gerard

AU - Winthrop, Kevin L.

AU - Mannino, David

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N2 - Rationale: Staphylococcus aureus is commonly cultured from the sputum of patients with bronchiectasis; however, little is known about the prevalence of the organism in these patients, the characteristics of patients who have grown the organism, or its implications. Objectives: Determine the relationship between S. aureus and pulmonary function, frequency of exacerbations, and frequency of hospitalization in patients with bronchiectasis Methods:TheBronchiectasisResearchRegistry is a database of adults with non-cystic fibrosis bronchiectasis identified from 13 sites within the United States. Baseline and follow-up demographic, spirometric, microbiologic, and therapeutic data were entered into a central webbased database. Patientswere grouped into three cohorts based on their previous respiratory cultures at the time of entry into theRegistry: 1) no prior S. aureus or glucose-nonfermenting gram-negative bacilli (NFGNB) (Pseudomonas, Stenotrophomonas, or Burkholderia spp.); 2) prior S. aureus at least once; or 3) no prior S. aureus but prior NF-GNB at least once. The association between S. aureus isolation and pulmonary function and frequency of exacerbations and hospital admissions was assessed, both at baseline and after 1 year of follow-up. Results: S. aureus was cultured from 94 of 830 patients (11.3%) included in the analysis. Patients who had grown S. aureus before entry into the Registry had a frequency of prior exacerbations and baseline pulmonary function that was between that of patients who had grown NF-GNB and those who had grown neither NF-GNB or S. aureus. Similarly, at the first follow-up visit after study entry, patients who had grown S. aureus had a frequency of exacerbations and hospitalizations that was between those of patients who had grown NF-GNB and those who had grown neither NF-GNB nor S. aureus. However, in multivariate analysis, S. aureus was not associated with pulmonary function, frequency of exacerbation, or hospital admissions. There were no significant differences in patient characteristics or outcomes between patients who had methicillin-sensitive and methicillin-resistant S. aureus. Conclusions: Staphylococcus aureus does not appear to be an independent risk factor for severe disease in patients with bronchiectasis enrolled in the Bronchiectasis Research Registry.

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KW - Methicillinresistant Staphylococcus aureus

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