The present and future disease burden of hepatitis C virus infections with today's treatment paradigm: Volume 4

H. L.Y. Chan; C. J. Chen; O. Omede; J. Al Qamish; K. Al Naamani; A. Bane; S. S. Tan; M. Simonova; I. Cardenas; M. Derbala; O. Akin; R. O. Phillips; M. K. Abdelmageed; M. Abdulla; D. Adda; A. Al Baqali; N. Al Dweik; K. Al Ejji; I. Al ghazzawi; S. Al Kaabi; M. Al Sadadi; J. Al Salman; M. AlBadri; S. A. Al-Busafi; H. E. Al-Romaihi; W. Ampofo; K. Antonov; C. Anyaike; F. Arome; S. Blach; M. M. Borodo; S. M. Brandon; B. Bright; M. T. Butt; D. S. Chen; P. J. Chen; R. N. Chien; W. L. Chuang; D. Cuellar; A. A. Elbardiny; C. Estes; E. Farag; J. Fung; I. Gamkrelidze; V. Garcia; J. Genov; Z. Ghandour; M. Ghuloom; B. Gomez; J. Gunter; J. Habeeb; O. Hajelssedig; W. Hamoudi; S. M. Himatt; I. Hrstic; C. C. Hu; C. F. Huang; Y. T. Hui; R. Jahis; D. Jelev; A. K. John; K. S. Kaliaskarova; Y. Kamel; J. H. Kao; J. Khamis; H. Khattabi; I. Khoudri; A. Konysbekova; I. Kotzev; M. S. Lai; W. C. Lao; J. Layden; M. H. Lee; O. Lesi; M. Li; A. Lo; C. K. Loo; B. Lukšić; A. Maaroufi; A. O. Malu; L. Mateva; R. Mitova; R. Mohamed; M. Morović; K. Murphy; B. Mustapha; A. Nersesov; E. Ngige; R. Njouom; O. Njoya; D. Nonković; S. Obekpa; S. Oguche; E. E. Okolo; C. Omuemu; P. Ondoa; O. Opare-Sem; S. Owusu-Ofori; Y. N. Prokopenko; H. Razavi; D. Razavi-Shearer; K. Razavi-Shearer; B. Redae; T. Reic; T. Rinke de Wit; C. Rios; S. Robbins; L. R. Roberts; S. J. Sanad; J. D. Schmelzer; M. Sharma; T. H. Su; K. Sultan; K. Tchernev; O. T.Y. Tsang; S. Tsang; C. Tzeuton; S. Ugoeze; B. Uzochukwu; R. Vi; A. Vince; H. U. Wani; V. W.S. Wong; A. Workneh; R. Yacoub; K. I. Yesmembetov; M. Youbi; M. F. Yuen; H. Nde

doi:10.1111/jvh.12760

The present and future disease burden of hepatitis C virus infections with today's treatment paradigm: Volume 4

H. L.Y. Chan, C. J. Chen, O. Omede, J. Al Qamish, K. Al Naamani, A. Bane, S. S. Tan, M. Simonova, I. Cardenas, M. Derbala, O. Akin, R. O. Phillips, M. K. Abdelmageed, M. Abdulla, D. Adda, A. Al Baqali, N. Al Dweik, K. Al Ejji, I. Al ghazzawi, S. Al KaabiM. Al Sadadi, J. Al Salman, M. AlBadri, S. A. Al-Busafi, H. E. Al-Romaihi, W. Ampofo, K. Antonov, C. Anyaike, F. Arome, S. Blach, M. M. Borodo, S. M. Brandon, B. Bright, M. T. Butt, D. S. Chen, P. J. Chen, R. N. Chien, W. L. Chuang, D. Cuellar, A. A. Elbardiny, C. Estes, E. Farag, J. Fung, I. Gamkrelidze, V. Garcia, J. Genov, Z. Ghandour, M. Ghuloom, B. Gomez, J. Gunter, J. Habeeb, O. Hajelssedig, W. Hamoudi, S. M. Himatt, I. Hrstic, C. C. Hu, C. F. Huang, Y. T. Hui, R. Jahis, D. Jelev, A. K. John, K. S. Kaliaskarova, Y. Kamel, J. H. Kao, J. Khamis, H. Khattabi, I. Khoudri, A. Konysbekova, I. Kotzev, M. S. Lai, W. C. Lao, J. Layden, M. H. Lee, O. Lesi, M. Li, A. Lo, C. K. Loo, B. Lukšić, A. Maaroufi, A. O. Malu, L. Mateva, R. Mitova, R. Mohamed, M. Morović, K. Murphy, B. Mustapha, A. Nersesov, E. Ngige, R. Njouom, O. Njoya, D. Nonković, S. Obekpa, S. Oguche, E. E. Okolo, C. Omuemu, P. Ondoa, O. Opare-Sem, S. Owusu-Ofori, Y. N. Prokopenko, H. Razavi, D. Razavi-Shearer, K. Razavi-Shearer, B. Redae, T. Reic, T. Rinke de Wit, C. Rios, S. Robbins, L. R. Roberts, S. J. Sanad, J. D. Schmelzer, M. Sharma, T. H. Su, K. Sultan, K. Tchernev, O. T.Y. Tsang, S. Tsang, C. Tzeuton, S. Ugoeze, B. Uzochukwu, R. Vi, A. Vince, H. U. Wani, V. W.S. Wong, A. Workneh, R. Yacoub, K. I. Yesmembetov, M. Youbi, M. F. Yuen, H. Nde

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Factors influencing the morbidity and mortality associated with viremic hepatitis C virus (HCV) infection change over time and place, making it difficult to compare reported estimates. Models were developed for 17 countries (Bahrain, Bulgaria, Cameroon, Colombia, Croatia, Dominican Republic, Ethiopia, Ghana, Hong Kong, Jordan, Kazakhstan, Malaysia, Morocco, Nigeria, Qatar and Taiwan) to quantify and characterize the viremic population as well as forecast the changes in the infected population and the corresponding disease burden from 2015 to 2030. Model inputs were agreed upon through expert consensus, and a standardized methodology was followed to allow for comparison across countries. The viremic prevalence is expected to remain constant or decline in all but four countries (Ethiopia, Ghana, Jordan and Oman); however, HCV-related morbidity and mortality will increase in all countries except Qatar and Taiwan. In Qatar, the high-treatment rate will contribute to a reduction in total cases and HCV-related morbidity by 2030. In the remaining countries, however, the current treatment paradigm will be insufficient to achieve large reductions in HCV-related morbidity and mortality.

Original language	English (US)
Pages (from-to)	25-43
Number of pages	19
Journal	Journal of viral hepatitis
Volume	24
DOIs	https://doi.org/10.1111/jvh.12760
State	Published - Oct 2017

Keywords

HCV
diagnosis
disease burden
epidemiology
hepatitis C
incidence
mortality
prevalence
treatment

ASJC Scopus subject areas

Hepatology
Infectious Diseases
Virology

Access to Document

10.1111/jvh.12760

Cite this

Chan, H. L. Y., Chen, C. J., Omede, O., Al Qamish, J., Al Naamani, K., Bane, A., Tan, S. S., Simonova, M., Cardenas, I., Derbala, M., Akin, O., Phillips, R. O., Abdelmageed, M. K., Abdulla, M., Adda, D., Al Baqali, A., Al Dweik, N., Al Ejji, K., Al ghazzawi, I., ... Nde, H. (2017). The present and future disease burden of hepatitis C virus infections with today's treatment paradigm: Volume 4. Journal of viral hepatitis, 24, 25-43. https://doi.org/10.1111/jvh.12760

Chan, HLY, Chen, CJ, Omede, O, Al Qamish, J, Al Naamani, K, Bane, A, Tan, SS, Simonova, M, Cardenas, I, Derbala, M, Akin, O, Phillips, RO, Abdelmageed, MK, Abdulla, M, Adda, D, Al Baqali, A, Al Dweik, N, Al Ejji, K, Al ghazzawi, I, Al Kaabi, S, Al Sadadi, M, Al Salman, J, AlBadri, M, Al-Busafi, SA, Al-Romaihi, HE, Ampofo, W, Antonov, K, Anyaike, C, Arome, F, Blach, S, Borodo, MM, Brandon, SM, Bright, B, Butt, MT, Chen, DS, Chen, PJ, Chien, RN, Chuang, WL, Cuellar, D, Elbardiny, AA, Estes, C, Farag, E, Fung, J, Gamkrelidze, I, Garcia, V, Genov, J, Ghandour, Z, Ghuloom, M, Gomez, B, Gunter, J, Habeeb, J, Hajelssedig, O, Hamoudi, W, Himatt, SM, Hrstic, I, Hu, CC, Huang, CF, Hui, YT, Jahis, R, Jelev, D, John, AK, Kaliaskarova, KS, Kamel, Y, Kao, JH, Khamis, J, Khattabi, H, Khoudri, I, Konysbekova, A, Kotzev, I, Lai, MS, Lao, WC, Layden, J, Lee, MH, Lesi, O, Li, M, Lo, A, Loo, CK, Lukšić, B, Maaroufi, A, Malu, AO, Mateva, L, Mitova, R, Mohamed, R, Morović, M, Murphy, K, Mustapha, B, Nersesov, A, Ngige, E, Njouom, R, Njoya, O, Nonković, D, Obekpa, S, Oguche, S, Okolo, EE, Omuemu, C, Ondoa, P, Opare-Sem, O, Owusu-Ofori, S, Prokopenko, YN, Razavi, H, Razavi-Shearer, D, Razavi-Shearer, K, Redae, B, Reic, T, Rinke de Wit, T, Rios, C, Robbins, S, Roberts, LR, Sanad, SJ, Schmelzer, JD, Sharma, M, Su, TH, Sultan, K, Tchernev, K, Tsang, OTY, Tsang, S, Tzeuton, C, Ugoeze, S, Uzochukwu, B, Vi, R, Vince, A, Wani, HU, Wong, VWS, Workneh, A, Yacoub, R, Yesmembetov, KI, Youbi, M, Yuen, MF & Nde, H 2017, 'The present and future disease burden of hepatitis C virus infections with today's treatment paradigm: Volume 4', Journal of viral hepatitis, vol. 24, pp. 25-43. https://doi.org/10.1111/jvh.12760

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title = "The present and future disease burden of hepatitis C virus infections with today's treatment paradigm: Volume 4",

abstract = "Factors influencing the morbidity and mortality associated with viremic hepatitis C virus (HCV) infection change over time and place, making it difficult to compare reported estimates. Models were developed for 17 countries (Bahrain, Bulgaria, Cameroon, Colombia, Croatia, Dominican Republic, Ethiopia, Ghana, Hong Kong, Jordan, Kazakhstan, Malaysia, Morocco, Nigeria, Qatar and Taiwan) to quantify and characterize the viremic population as well as forecast the changes in the infected population and the corresponding disease burden from 2015 to 2030. Model inputs were agreed upon through expert consensus, and a standardized methodology was followed to allow for comparison across countries. The viremic prevalence is expected to remain constant or decline in all but four countries (Ethiopia, Ghana, Jordan and Oman); however, HCV-related morbidity and mortality will increase in all countries except Qatar and Taiwan. In Qatar, the high-treatment rate will contribute to a reduction in total cases and HCV-related morbidity by 2030. In the remaining countries, however, the current treatment paradigm will be insufficient to achieve large reductions in HCV-related morbidity and mortality.",

keywords = "HCV, diagnosis, disease burden, epidemiology, hepatitis C, incidence, mortality, prevalence, treatment",

author = "Chan, {H. L.Y.} and Chen, {C. J.} and O. Omede and {Al Qamish}, J. and {Al Naamani}, K. and A. Bane and Tan, {S. S.} and M. Simonova and I. Cardenas and M. Derbala and O. Akin and Phillips, {R. O.} and Abdelmageed, {M. K.} and M. Abdulla and D. Adda and {Al Baqali}, A. and {Al Dweik}, N. and {Al Ejji}, K. and {Al ghazzawi}, I. and {Al Kaabi}, S. and {Al Sadadi}, M. and {Al Salman}, J. and M. AlBadri and Al-Busafi, {S. A.} and Al-Romaihi, {H. E.} and W. Ampofo and K. Antonov and C. Anyaike and F. Arome and S. Blach and Borodo, {M. M.} and Brandon, {S. M.} and B. Bright and Butt, {M. T.} and Chen, {D. S.} and Chen, {P. J.} and Chien, {R. N.} and Chuang, {W. L.} and D. Cuellar and Elbardiny, {A. A.} and C. Estes and E. Farag and J. Fung and I. Gamkrelidze and V. Garcia and J. Genov and Z. Ghandour and M. Ghuloom and B. Gomez and J. Gunter and J. Habeeb and O. Hajelssedig and W. Hamoudi and Himatt, {S. M.} and I. Hrstic and Hu, {C. C.} and Huang, {C. F.} and Hui, {Y. T.} and R. Jahis and D. Jelev and John, {A. K.} and Kaliaskarova, {K. S.} and Y. Kamel and Kao, {J. H.} and J. Khamis and H. Khattabi and I. Khoudri and A. Konysbekova and I. Kotzev and Lai, {M. S.} and Lao, {W. C.} and J. Layden and Lee, {M. H.} and O. Lesi and M. Li and A. Lo and Loo, {C. K.} and B. Luk{\v s}i{\'c} and A. Maaroufi and Malu, {A. O.} and L. Mateva and R. Mitova and R. Mohamed and M. Morovi{\'c} and K. Murphy and B. Mustapha and A. Nersesov and E. Ngige and R. Njouom and O. Njoya and D. Nonkovi{\'c} and S. Obekpa and S. Oguche and Okolo, {E. E.} and C. Omuemu and P. Ondoa and O. Opare-Sem and S. Owusu-Ofori and Prokopenko, {Y. N.} and H. Razavi and D. Razavi-Shearer and K. Razavi-Shearer and B. Redae and T. Reic and {Rinke de Wit}, T. and C. Rios and S. Robbins and Roberts, {L. R.} and Sanad, {S. J.} and Schmelzer, {J. D.} and M. Sharma and Su, {T. H.} and K. Sultan and K. Tchernev and Tsang, {O. T.Y.} and S. Tsang and C. Tzeuton and S. Ugoeze and B. Uzochukwu and R. Vi and A. Vince and Wani, {H. U.} and Wong, {V. W.S.} and A. Workneh and R. Yacoub and Yesmembetov, {K. I.} and M. Youbi and Yuen, {M. F.} and H. Nde",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors. Journal of Viral Hepatitis Published by John Wiley & Sons Ltd.",

year = "2017",

month = oct,

doi = "10.1111/jvh.12760",

language = "English (US)",

volume = "24",

pages = "25--43",

journal = "Journal of viral hepatitis",

issn = "1352-0504",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - The present and future disease burden of hepatitis C virus infections with today's treatment paradigm

T2 - Volume 4

AU - Chan, H. L.Y.

AU - Chen, C. J.

AU - Omede, O.

AU - Al Qamish, J.

AU - Al Naamani, K.

AU - Bane, A.

AU - Tan, S. S.

AU - Simonova, M.

AU - Cardenas, I.

AU - Derbala, M.

AU - Akin, O.

AU - Phillips, R. O.

AU - Abdelmageed, M. K.

AU - Abdulla, M.

AU - Adda, D.

AU - Al Baqali, A.

AU - Al Dweik, N.

AU - Al Ejji, K.

AU - Al ghazzawi, I.

AU - Al Kaabi, S.

AU - Al Sadadi, M.

AU - Al Salman, J.

AU - AlBadri, M.

AU - Al-Busafi, S. A.

AU - Al-Romaihi, H. E.

AU - Ampofo, W.

AU - Antonov, K.

AU - Anyaike, C.

AU - Arome, F.

AU - Blach, S.

AU - Borodo, M. M.

AU - Brandon, S. M.

AU - Bright, B.

AU - Butt, M. T.

AU - Chen, D. S.

AU - Chen, P. J.

AU - Chien, R. N.

AU - Chuang, W. L.

AU - Cuellar, D.

AU - Elbardiny, A. A.

AU - Estes, C.

AU - Farag, E.

AU - Fung, J.

AU - Gamkrelidze, I.

AU - Garcia, V.

AU - Genov, J.

AU - Ghandour, Z.

AU - Ghuloom, M.

AU - Gomez, B.

AU - Gunter, J.

AU - Habeeb, J.

AU - Hajelssedig, O.

AU - Hamoudi, W.

AU - Himatt, S. M.

AU - Hrstic, I.

AU - Hu, C. C.

AU - Huang, C. F.

AU - Hui, Y. T.

AU - Jahis, R.

AU - Jelev, D.

AU - John, A. K.

AU - Kaliaskarova, K. S.

AU - Kamel, Y.

AU - Kao, J. H.

AU - Khamis, J.

AU - Khattabi, H.

AU - Khoudri, I.

AU - Konysbekova, A.

AU - Kotzev, I.

AU - Lai, M. S.

AU - Lao, W. C.

AU - Layden, J.

AU - Lee, M. H.

AU - Lesi, O.

AU - Li, M.

AU - Lo, A.

AU - Loo, C. K.

AU - Lukšić, B.

AU - Maaroufi, A.

AU - Malu, A. O.

AU - Mateva, L.

AU - Mitova, R.

AU - Mohamed, R.

AU - Morović, M.

AU - Murphy, K.

AU - Mustapha, B.

AU - Nersesov, A.

AU - Ngige, E.

AU - Njouom, R.

AU - Njoya, O.

AU - Nonković, D.

AU - Obekpa, S.

AU - Oguche, S.

AU - Okolo, E. E.

AU - Omuemu, C.

AU - Ondoa, P.

AU - Opare-Sem, O.

AU - Owusu-Ofori, S.

AU - Prokopenko, Y. N.

AU - Razavi, H.

AU - Razavi-Shearer, D.

AU - Razavi-Shearer, K.

AU - Redae, B.

AU - Reic, T.

AU - Rinke de Wit, T.

AU - Rios, C.

AU - Robbins, S.

AU - Roberts, L. R.

AU - Sanad, S. J.

AU - Schmelzer, J. D.

AU - Sharma, M.

AU - Su, T. H.

AU - Sultan, K.

AU - Tchernev, K.

AU - Tsang, O. T.Y.

AU - Tsang, S.

AU - Tzeuton, C.

AU - Ugoeze, S.

AU - Uzochukwu, B.

AU - Vi, R.

AU - Vince, A.

AU - Wani, H. U.

AU - Wong, V. W.S.

AU - Workneh, A.

AU - Yacoub, R.

AU - Yesmembetov, K. I.

AU - Youbi, M.

AU - Yuen, M. F.

AU - Nde, H.

PY - 2017/10

Y1 - 2017/10

N2 - Factors influencing the morbidity and mortality associated with viremic hepatitis C virus (HCV) infection change over time and place, making it difficult to compare reported estimates. Models were developed for 17 countries (Bahrain, Bulgaria, Cameroon, Colombia, Croatia, Dominican Republic, Ethiopia, Ghana, Hong Kong, Jordan, Kazakhstan, Malaysia, Morocco, Nigeria, Qatar and Taiwan) to quantify and characterize the viremic population as well as forecast the changes in the infected population and the corresponding disease burden from 2015 to 2030. Model inputs were agreed upon through expert consensus, and a standardized methodology was followed to allow for comparison across countries. The viremic prevalence is expected to remain constant or decline in all but four countries (Ethiopia, Ghana, Jordan and Oman); however, HCV-related morbidity and mortality will increase in all countries except Qatar and Taiwan. In Qatar, the high-treatment rate will contribute to a reduction in total cases and HCV-related morbidity by 2030. In the remaining countries, however, the current treatment paradigm will be insufficient to achieve large reductions in HCV-related morbidity and mortality.

AB - Factors influencing the morbidity and mortality associated with viremic hepatitis C virus (HCV) infection change over time and place, making it difficult to compare reported estimates. Models were developed for 17 countries (Bahrain, Bulgaria, Cameroon, Colombia, Croatia, Dominican Republic, Ethiopia, Ghana, Hong Kong, Jordan, Kazakhstan, Malaysia, Morocco, Nigeria, Qatar and Taiwan) to quantify and characterize the viremic population as well as forecast the changes in the infected population and the corresponding disease burden from 2015 to 2030. Model inputs were agreed upon through expert consensus, and a standardized methodology was followed to allow for comparison across countries. The viremic prevalence is expected to remain constant or decline in all but four countries (Ethiopia, Ghana, Jordan and Oman); however, HCV-related morbidity and mortality will increase in all countries except Qatar and Taiwan. In Qatar, the high-treatment rate will contribute to a reduction in total cases and HCV-related morbidity by 2030. In the remaining countries, however, the current treatment paradigm will be insufficient to achieve large reductions in HCV-related morbidity and mortality.

KW - HCV

KW - diagnosis

KW - disease burden

KW - epidemiology

KW - hepatitis C

KW - incidence

KW - mortality

KW - prevalence

KW - treatment

UR - http://www.scopus.com/inward/record.url?scp=85032955067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032955067&partnerID=8YFLogxK

U2 - 10.1111/jvh.12760

DO - 10.1111/jvh.12760

M3 - Article

C2 - 29105283

AN - SCOPUS:85032955067

SN - 1352-0504

VL - 24

SP - 25

EP - 43

JO - Journal of viral hepatitis

JF - Journal of viral hepatitis

ER -

The present and future disease burden of hepatitis C virus infections with today's treatment paradigm: Volume 4

Abstract

Keywords

ASJC Scopus subject areas

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