The presence of active hepatitis C virus replication in lymphoid tissue in patients coinfected with human immunodeficiency virus type 1

Tomasz Laskus, Marek Radkowski, Lian Fu Wang, Hugo E Vargas, Jorge Rakela

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Abstract

The existence of extrahepatic replication sites of hepatitis C virus (HCV) remains controversial. Highly strand-specific Tth-based reverse transcriptase-polymerase chain reaction was used to search for the presence of viral RNA negative strand in lymph nodes from 16 patients with AIDS and in peripheral blood mononuclear cells (PBMC) from 14 other human immunodeficiency virus (HIV)positive patients. Negative-strand HCV RNA was detected in lymph node samples from 10 patients (63%) and in PBMC from 5 (36%). This suggests that, at least under circumstances of impaired immunity associated with HIV infection, HCV is lymphotropic in vivo. However, the clinical implications of these findings need to be further investigated.

Original languageEnglish (US)
Pages (from-to)1189-1192
Number of pages4
JournalJournal of Infectious Diseases
Volume178
Issue number4
StatePublished - 1998
Externally publishedYes

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Lymphoid Tissue
Virus Replication
Hepacivirus
HIV-1
Blood Cells
Lymph Nodes
HIV
Viral RNA
Virus Diseases
Reverse Transcriptase Polymerase Chain Reaction
Immunity
Acquired Immunodeficiency Syndrome
RNA

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

The presence of active hepatitis C virus replication in lymphoid tissue in patients coinfected with human immunodeficiency virus type 1. / Laskus, Tomasz; Radkowski, Marek; Wang, Lian Fu; Vargas, Hugo E; Rakela, Jorge.

In: Journal of Infectious Diseases, Vol. 178, No. 4, 1998, p. 1189-1192.

Research output: Contribution to journalArticle

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