The practice of reporting transfusion-related acute lung injury: A national survey among clinical and preclinical disciplines

Alexander P. Vlaar, Kim Wortel, Jan M. Binnekade, Marinus H J Van Oers, Erik Beckers, Ognjen Gajic, Marcus J. Schultz, Nicole P. Juffermans

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Transfusion-related acute lung injury (TRALI) is hypothesized to be a "two-hit" entity, in which an inflammatory condition (e.g., sepsis) predisposes to TRALI. TRALI is a clinical diagnosis. Disciplines involved in managing TRALI may differ in decision-making on the reporting of TRALI. Study Design and Methods: A survey was conducted among critical care physicians, hematologists, hemovigilance workers, and transfusion medicine physicians, using case vignettes and a questionnaire. The vignettes varied in patient- and blood product-related factors that may influence the decision to report a TRALI case. Multiple linear regression analysis was performed. A positive β-coefficient is in favor of reporting. Results: Ninety-two questionnaires were returned (response rate, 68%). For all disciplines, preferences in favor of reporting TRALI were onset of symptoms within 1 hour (β = 0.4), after transfusion of a single unit of FFP (β = 0.5), and in the absence of acute lung injury before transfusion (β = 1.3). An admission diagnosis of sepsis was a negative preference (β = -0.3). Massive transfusion (6 RBC plus 4 FFP units) was a negative preference for transfusion medicine physicians (β = -0.3), but a positive preference for the other disciplines. The questionnaire revealed that massive transfusion and the age of blood products were considered relatively more important reasons to report TRALI by critical care physicians compared to the other disciplines (p < 0.05). Conclusion: A pretransfusion inflammatory condition is a reason to withhold from reporting of a suspected TRALI case. Disciplines involved in managing TRALI differ in decision-making of reporting TRALI, which may contribute to variance in incidence.

Original languageEnglish (US)
Pages (from-to)443-451
Number of pages9
JournalTransfusion
Volume50
Issue number2
DOIs
StatePublished - Feb 2010

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Acute Lung Injury
Transfusion Medicine
Physicians
Critical Care
Surveys and Questionnaires
Sepsis
Decision Making
Blood Safety
Blood Transfusion
Linear Models
Regression Analysis

ASJC Scopus subject areas

  • Hematology
  • Immunology
  • Immunology and Allergy

Cite this

The practice of reporting transfusion-related acute lung injury : A national survey among clinical and preclinical disciplines. / Vlaar, Alexander P.; Wortel, Kim; Binnekade, Jan M.; Van Oers, Marinus H J; Beckers, Erik; Gajic, Ognjen; Schultz, Marcus J.; Juffermans, Nicole P.

In: Transfusion, Vol. 50, No. 2, 02.2010, p. 443-451.

Research output: Contribution to journalArticle

Vlaar, AP, Wortel, K, Binnekade, JM, Van Oers, MHJ, Beckers, E, Gajic, O, Schultz, MJ & Juffermans, NP 2010, 'The practice of reporting transfusion-related acute lung injury: A national survey among clinical and preclinical disciplines', Transfusion, vol. 50, no. 2, pp. 443-451. https://doi.org/10.1111/j.1537-2995.2009.02415.x
Vlaar, Alexander P. ; Wortel, Kim ; Binnekade, Jan M. ; Van Oers, Marinus H J ; Beckers, Erik ; Gajic, Ognjen ; Schultz, Marcus J. ; Juffermans, Nicole P. / The practice of reporting transfusion-related acute lung injury : A national survey among clinical and preclinical disciplines. In: Transfusion. 2010 ; Vol. 50, No. 2. pp. 443-451.
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AB - Background: Transfusion-related acute lung injury (TRALI) is hypothesized to be a "two-hit" entity, in which an inflammatory condition (e.g., sepsis) predisposes to TRALI. TRALI is a clinical diagnosis. Disciplines involved in managing TRALI may differ in decision-making on the reporting of TRALI. Study Design and Methods: A survey was conducted among critical care physicians, hematologists, hemovigilance workers, and transfusion medicine physicians, using case vignettes and a questionnaire. The vignettes varied in patient- and blood product-related factors that may influence the decision to report a TRALI case. Multiple linear regression analysis was performed. A positive β-coefficient is in favor of reporting. Results: Ninety-two questionnaires were returned (response rate, 68%). For all disciplines, preferences in favor of reporting TRALI were onset of symptoms within 1 hour (β = 0.4), after transfusion of a single unit of FFP (β = 0.5), and in the absence of acute lung injury before transfusion (β = 1.3). An admission diagnosis of sepsis was a negative preference (β = -0.3). Massive transfusion (6 RBC plus 4 FFP units) was a negative preference for transfusion medicine physicians (β = -0.3), but a positive preference for the other disciplines. The questionnaire revealed that massive transfusion and the age of blood products were considered relatively more important reasons to report TRALI by critical care physicians compared to the other disciplines (p < 0.05). Conclusion: A pretransfusion inflammatory condition is a reason to withhold from reporting of a suspected TRALI case. Disciplines involved in managing TRALI differ in decision-making of reporting TRALI, which may contribute to variance in incidence.

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