The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Alex J. Thompson, Michael Hughes, Salzitsa Anastasova, Laurie S. Conklin, Tudor Thomas, Cadman Leggett, William Alvis Faubion, Thomas J. Miller, Peter Delaney, François Lacombe, Sacha Loiseau, Alexander Meining, Rebecca Richards-Kortum, Guillermo J. Tearney, Paul Kelly, Guang Zhong Yang

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading-to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress-towards new biomarkers and interventions for EED is hampered by the practical and'ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical'biopsy techniques ' which can provide minimally invasive or noninvasive alternatives to'biopsy' could offer other routes to validation and could potentially be used as point?of?care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care.

Original languageEnglish (US)
Pages (from-to)727-738
Number of pages12
JournalNature Reviews Gastroenterology and Hepatology
Volume14
Issue number12
DOIs
StatePublished - Dec 1 2017

Fingerprint

Biopsy
Growth Disorders
Celiac Disease
Graft vs Host Disease
Critical Care
Small Intestine
Histology
Transplantation
Biomarkers
Inflammation
Technology
Infection
Population
Autoimmune enteropathy

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction. / Thompson, Alex J.; Hughes, Michael; Anastasova, Salzitsa; Conklin, Laurie S.; Thomas, Tudor; Leggett, Cadman; Faubion, William Alvis; Miller, Thomas J.; Delaney, Peter; Lacombe, François; Loiseau, Sacha; Meining, Alexander; Richards-Kortum, Rebecca; Tearney, Guillermo J.; Kelly, Paul; Yang, Guang Zhong.

In: Nature Reviews Gastroenterology and Hepatology, Vol. 14, No. 12, 01.12.2017, p. 727-738.

Research output: Contribution to journalReview article

Thompson, AJ, Hughes, M, Anastasova, S, Conklin, LS, Thomas, T, Leggett, C, Faubion, WA, Miller, TJ, Delaney, P, Lacombe, F, Loiseau, S, Meining, A, Richards-Kortum, R, Tearney, GJ, Kelly, P & Yang, GZ 2017, 'The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction', Nature Reviews Gastroenterology and Hepatology, vol. 14, no. 12, pp. 727-738. https://doi.org/10.1038/nrgastro.2017.147
Thompson, Alex J. ; Hughes, Michael ; Anastasova, Salzitsa ; Conklin, Laurie S. ; Thomas, Tudor ; Leggett, Cadman ; Faubion, William Alvis ; Miller, Thomas J. ; Delaney, Peter ; Lacombe, François ; Loiseau, Sacha ; Meining, Alexander ; Richards-Kortum, Rebecca ; Tearney, Guillermo J. ; Kelly, Paul ; Yang, Guang Zhong. / The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction. In: Nature Reviews Gastroenterology and Hepatology. 2017 ; Vol. 14, No. 12. pp. 727-738.
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