The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function

Pradeep L. Ramachandran; Theodore A. Craig; Elena A. Atanasova; Gaofeng Cui; Barbara A. Owen; H. Robert Bergen; Georges Mer; Rajiv Kumar

doi:10.1074/jbc.M112.398495

The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function

Pradeep L. Ramachandran, Theodore A. Craig, Elena A. Atanasova, Gaofeng Cui, Barbara A. Owen, H. Robert Bergen, Georges Mer, Rajiv Kumar

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background: The calcium-binding protein DREAM/KChIP3 binds DNA and other proteins to regulate neuronal function. Results: DREAM/KChIP3 binds the EF-hand protein, calmodulin, in the presence but not in the absence of calcium. Calciumbound DREAM/KChIP3 enhances calmodulin-dependent calcineurin activity. Conclusion: DREAM/KChIP3 binds and regulates calmodulin activity. Significance: DREAM/KChIP3 heterodimerizes with the EF-hand protein, calmodulin, and regulates calmodulin activation of calcineurin.

Original language	English (US)
Pages (from-to)	39439-39448
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	287
Issue number	47
DOIs	https://doi.org/10.1074/jbc.M112.398495
State	Published - Nov 16 2012

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function. / Ramachandran, Pradeep L.; Craig, Theodore A.; Atanasova, Elena A.; Cui, Gaofeng; Owen, Barbara A.; Bergen, H. Robert ; Mer, Georges ; Kumar, Rajiv.

In: Journal of Biological Chemistry, Vol. 287, No. 47, 16.11.2012, p. 39439-39448.

Research output: Contribution to journal › Article › peer-review

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title = "The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function",

abstract = "Background: The calcium-binding protein DREAM/KChIP3 binds DNA and other proteins to regulate neuronal function. Results: DREAM/KChIP3 binds the EF-hand protein, calmodulin, in the presence but not in the absence of calcium. Calciumbound DREAM/KChIP3 enhances calmodulin-dependent calcineurin activity. Conclusion: DREAM/KChIP3 binds and regulates calmodulin activity. Significance: DREAM/KChIP3 heterodimerizes with the EF-hand protein, calmodulin, and regulates calmodulin activation of calcineurin.",

author = "Ramachandran, {Pradeep L.} and Craig, {Theodore A.} and Atanasova, {Elena A.} and Gaofeng Cui and Owen, {Barbara A.} and Bergen, {H. Robert} and Georges Mer and Rajiv Kumar",

note = "Funding Information: * This work was supported, in whole or in part, by National Institutes of Health Grants AR-058003 and AR-60869. This work was also supported by a grant from the Marion and Ralph Falk Medical Trust.",

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T1 - The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function

AU - Ramachandran, Pradeep L.

AU - Craig, Theodore A.

AU - Atanasova, Elena A.

AU - Cui, Gaofeng

AU - Owen, Barbara A.

AU - Bergen, H. Robert

AU - Mer, Georges

AU - Kumar, Rajiv

N1 - Funding Information: * This work was supported, in whole or in part, by National Institutes of Health Grants AR-058003 and AR-60869. This work was also supported by a grant from the Marion and Ralph Falk Medical Trust.

PY - 2012/11/16

Y1 - 2012/11/16

N2 - Background: The calcium-binding protein DREAM/KChIP3 binds DNA and other proteins to regulate neuronal function. Results: DREAM/KChIP3 binds the EF-hand protein, calmodulin, in the presence but not in the absence of calcium. Calciumbound DREAM/KChIP3 enhances calmodulin-dependent calcineurin activity. Conclusion: DREAM/KChIP3 binds and regulates calmodulin activity. Significance: DREAM/KChIP3 heterodimerizes with the EF-hand protein, calmodulin, and regulates calmodulin activation of calcineurin.

AB - Background: The calcium-binding protein DREAM/KChIP3 binds DNA and other proteins to regulate neuronal function. Results: DREAM/KChIP3 binds the EF-hand protein, calmodulin, in the presence but not in the absence of calcium. Calciumbound DREAM/KChIP3 enhances calmodulin-dependent calcineurin activity. Conclusion: DREAM/KChIP3 binds and regulates calmodulin activity. Significance: DREAM/KChIP3 heterodimerizes with the EF-hand protein, calmodulin, and regulates calmodulin activation of calcineurin.

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