The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function

Pradeep L. Ramachandran, Theodore A. Craig, Elena A. Atanasova, Gaofeng Cui, Barbara A. Owen, H. Robert Bergen, Georges Mer, Rajiv Kumar

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: The calcium-binding protein DREAM/KChIP3 binds DNA and other proteins to regulate neuronal function. Results: DREAM/KChIP3 binds the EF-hand protein, calmodulin, in the presence but not in the absence of calcium. Calciumbound DREAM/KChIP3 enhances calmodulin-dependent calcineurin activity. Conclusion: DREAM/KChIP3 binds and regulates calmodulin activity. Significance: DREAM/KChIP3 heterodimerizes with the EF-hand protein, calmodulin, and regulates calmodulin activation of calcineurin.

Original languageEnglish (US)
Pages (from-to)39439-39448
Number of pages10
JournalJournal of Biological Chemistry
Volume287
Issue number47
DOIs
StatePublished - Nov 16 2012

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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