The possible contribution of anti-Gal to Graves' disease

Joseph Fullmer, Arnold Lindall, Rebecca Bahn, Cary N. Mariash

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Anti-Gal is a natural antibody specific for the α-galactosyl epitope. Previous studies suggested that Graves' disease (GD) patients had elevated anti-Gal titers compared to normal controls, but titers returned to normal after treatment. We developed an anti-Gal enzyme-linked immunosorbent assay (ELISA) using the property of anti-Gal to bind tightly to mouse laminin. We found no significant correlations between anti-Gal and thyroid-stimulating immunoglobulin (TSI) or free thyroxine (T4) in untreated hyperthyroid GD patients (n = 15) without clinical ophthalmopathy or euthyroid, previously treated GD patients with ophthalmopathy. There was a significant regression between TSI and free T4 in the hyperthyroid patients (p < 0.01). Addition of total anti-Gal antibody to the regression showed a trend toward improved correlation (p = 0.15 for improved correlation relative to TSI and free T 4 alone), suggesting it may stimulate GD thyroid tissue. However, in contrast to previous studies we found hyperthyroid patients (n = 20) had lower levels of anti-Gal immunoglobulin G (IgG) (18.4 ± 4.0 vs. 41.8 ± 8.9) than normals (n = 36 p < 0.05). Interestingly, hyperthyroid patients without clinical ophthalmopathy tended to have lower IgG anti-Gal levels than euthyroid patients with ophthalmopathy (p = 0.1). Hyperthyroidism significantly lowers anti-Gal, but the possible increase of anti-Gal in patients with ophthalmopathy suggests anti-Gal may play a role in ophthalmopathy, or may reflect the euthryoid status of these patients. This trend needs further study.

Original languageEnglish (US)
Pages (from-to)1239-1243
Number of pages5
JournalThyroid
Volume15
Issue number11
DOIs
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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