The pneumocystis Ace2 transcription factor regulates cell wall-remodeling genes and organism virulence

Theodore J. Kottom, Andrew Harold Limper

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Ace2 transcription factors regulate fungal cell wall remodeling. Results: Pneumocystis carinii Ace2 (PcAce2) is activated by lung matrix proteins and participates in fungal virulence. Conclusion: PcAce2 represents a key component of life cycle regulation that is induced by Pneumocystis contact with host substrates. Significance: This is the first example demonstrating a contact-induced activation of the Ace2 transcription factor.

Original languageEnglish (US)
Pages (from-to)23893-23902
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
StatePublished - Aug 16 2013

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Pneumocystis
Pneumocystis carinii
Cell Wall
Virulence
Transcription Factors
Genes
Cells
Life Cycle Stages
Life cycle
Chemical activation
Lung
Substrates
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

The pneumocystis Ace2 transcription factor regulates cell wall-remodeling genes and organism virulence. / Kottom, Theodore J.; Limper, Andrew Harold.

In: Journal of Biological Chemistry, Vol. 288, No. 33, 16.08.2013, p. 23893-23902.

Research output: Contribution to journalArticle

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