The pneumocystis Ace2 transcription factor regulates cell wall-remodeling genes and organism virulence

Theodore J. Kottom, Andrew H. Limper

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: Ace2 transcription factors regulate fungal cell wall remodeling. Results: Pneumocystis carinii Ace2 (PcAce2) is activated by lung matrix proteins and participates in fungal virulence. Conclusion: PcAce2 represents a key component of life cycle regulation that is induced by Pneumocystis contact with host substrates. Significance: This is the first example demonstrating a contact-induced activation of the Ace2 transcription factor.

Original languageEnglish (US)
Pages (from-to)23893-23902
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
StatePublished - Aug 16 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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