The pneumocystis Ace2 transcription factor regulates cell wall-remodeling genes and organism virulence

Theodore J. Kottom; Andrew H. Limper

doi:10.1074/jbc.M113.471243

The pneumocystis Ace2 transcription factor regulates cell wall-remodeling genes and organism virulence

Theodore J. Kottom, Andrew H. Limper

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Ace2 transcription factors regulate fungal cell wall remodeling. Results: Pneumocystis carinii Ace2 (PcAce2) is activated by lung matrix proteins and participates in fungal virulence. Conclusion: PcAce2 represents a key component of life cycle regulation that is induced by Pneumocystis contact with host substrates. Significance: This is the first example demonstrating a contact-induced activation of the Ace2 transcription factor.

Original language	English (US)
Pages (from-to)	23893-23902
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	33
DOIs	https://doi.org/10.1074/jbc.M113.471243
State	Published - Aug 16 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "The pneumocystis Ace2 transcription factor regulates cell wall-remodeling genes and organism virulence",

abstract = "Background: Ace2 transcription factors regulate fungal cell wall remodeling. Results: Pneumocystis carinii Ace2 (PcAce2) is activated by lung matrix proteins and participates in fungal virulence. Conclusion: PcAce2 represents a key component of life cycle regulation that is induced by Pneumocystis contact with host substrates. Significance: This is the first example demonstrating a contact-induced activation of the Ace2 transcription factor.",

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AU - Limper, Andrew H.

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N2 - Background: Ace2 transcription factors regulate fungal cell wall remodeling. Results: Pneumocystis carinii Ace2 (PcAce2) is activated by lung matrix proteins and participates in fungal virulence. Conclusion: PcAce2 represents a key component of life cycle regulation that is induced by Pneumocystis contact with host substrates. Significance: This is the first example demonstrating a contact-induced activation of the Ace2 transcription factor.

AB - Background: Ace2 transcription factors regulate fungal cell wall remodeling. Results: Pneumocystis carinii Ace2 (PcAce2) is activated by lung matrix proteins and participates in fungal virulence. Conclusion: PcAce2 represents a key component of life cycle regulation that is induced by Pneumocystis contact with host substrates. Significance: This is the first example demonstrating a contact-induced activation of the Ace2 transcription factor.

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The pneumocystis Ace2 transcription factor regulates cell wall-remodeling genes and organism virulence

Abstract

ASJC Scopus subject areas

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