The pituitary in Turner syndrome

B. W. Scheithauer, K. Kovacs, E. Horvath, William Francis Young, R. V. Lloyd

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Although Turner syndrome is not uncommon, studies of the pituitary in this condition are few. We undertook a histochemical and immunohistochemical study of four cases. As expected, "gonadal failure cells" were seen, but without recognizable gonadotroph hyperplasia. No gonadotroph adenomas were encountered. Instead, three silent corticotroph microadenomas were seen; their etiology remains unexplained. The question of whether the simultaneous occurrence of Turner syndrome and silent corticotroph adenoma is causal or incidental cannot be answered on the basis of the study of our material. Because these two diseases are rare, an etiologic association has to be considered. For example, it is possible that (a) protracted stimulation of gonadotrophs leads to transdifferentiation to corticotrophs, a hypothesis supported by the fact that normal and neoplastic gonadotrophs can contain ACTH and that some corticotroph adenomas produce LH and/or alpha subunit, (b) corticotrophs develop gonadotropin-releasing hormone (GnRH) receptors and undergo neoplastic transformation when exposed to continuous elevation of GnRH, FSH, and/or LH levels, and (c) the genetic defect in Turner syndrome promotes the formation of corticotroph adenomas.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalEndocrine Pathology
Volume16
Issue number3
DOIs
StatePublished - Sep 2005

Fingerprint

Gonadotrophs
Turner Syndrome
ACTH-Secreting Pituitary Adenoma
Corticotrophs
Alpha Subunit Glycoprotein Hormones
LHRH Receptors
Rare Diseases
Gonadotropin-Releasing Hormone
Adenoma
Adrenocorticotropic Hormone
Hyperplasia

Keywords

  • Pituitary
  • Turner syndrome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Scheithauer, B. W., Kovacs, K., Horvath, E., Young, W. F., & Lloyd, R. V. (2005). The pituitary in Turner syndrome. Endocrine Pathology, 16(3), 195-200. https://doi.org/10.1385/EP:16:3:195

The pituitary in Turner syndrome. / Scheithauer, B. W.; Kovacs, K.; Horvath, E.; Young, William Francis; Lloyd, R. V.

In: Endocrine Pathology, Vol. 16, No. 3, 09.2005, p. 195-200.

Research output: Contribution to journalArticle

Scheithauer, BW, Kovacs, K, Horvath, E, Young, WF & Lloyd, RV 2005, 'The pituitary in Turner syndrome', Endocrine Pathology, vol. 16, no. 3, pp. 195-200. https://doi.org/10.1385/EP:16:3:195
Scheithauer BW, Kovacs K, Horvath E, Young WF, Lloyd RV. The pituitary in Turner syndrome. Endocrine Pathology. 2005 Sep;16(3):195-200. https://doi.org/10.1385/EP:16:3:195
Scheithauer, B. W. ; Kovacs, K. ; Horvath, E. ; Young, William Francis ; Lloyd, R. V. / The pituitary in Turner syndrome. In: Endocrine Pathology. 2005 ; Vol. 16, No. 3. pp. 195-200.
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