Abstract
The apparent hypogonadism in patients with the Laurence-Moon syndrome has been variably attributed to unresponsiveness of target organs to gonadal hormones, primary end-organ failure, hypothalamic dysfunction, or pituitary failure. We report the first immunocytologic study of the pituitary gland in this rare disorder. No morphological abnormalities were noted. The numbers and immunoreactivities of adenohypophyseal cell types were normal. No microscopic abnormalities were evident in the hypothalamus and target organs. The results of our study are consistent with recent biochemical data that suggest that pituitary function is normal in patients with this syndrome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 216-222 |
| Number of pages | 7 |
| Journal | Mayo Clinic Proceedings |
| Volume | 62 |
| Issue number | 3 |
| State | Published - 1987 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
The pituitary gland in the Laurence-Moon syndrome. / Whitaker, M. D.; Scheithauer, B. W.; Kovacs, K. T.; Randall, R. V.; Campbell, R. J.; Okazaki, H.
In: Mayo Clinic Proceedings, Vol. 62, No. 3, 1987, p. 216-222.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The pituitary gland in the Laurence-Moon syndrome
AU - Whitaker, M. D.
AU - Scheithauer, B. W.
AU - Kovacs, K. T.
AU - Randall, R. V.
AU - Campbell, R. J.
AU - Okazaki, H.
PY - 1987
Y1 - 1987
N2 - The apparent hypogonadism in patients with the Laurence-Moon syndrome has been variably attributed to unresponsiveness of target organs to gonadal hormones, primary end-organ failure, hypothalamic dysfunction, or pituitary failure. We report the first immunocytologic study of the pituitary gland in this rare disorder. No morphological abnormalities were noted. The numbers and immunoreactivities of adenohypophyseal cell types were normal. No microscopic abnormalities were evident in the hypothalamus and target organs. The results of our study are consistent with recent biochemical data that suggest that pituitary function is normal in patients with this syndrome.
AB - The apparent hypogonadism in patients with the Laurence-Moon syndrome has been variably attributed to unresponsiveness of target organs to gonadal hormones, primary end-organ failure, hypothalamic dysfunction, or pituitary failure. We report the first immunocytologic study of the pituitary gland in this rare disorder. No morphological abnormalities were noted. The numbers and immunoreactivities of adenohypophyseal cell types were normal. No microscopic abnormalities were evident in the hypothalamus and target organs. The results of our study are consistent with recent biochemical data that suggest that pituitary function is normal in patients with this syndrome.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023145088&partnerID=8YFLogxK
M3 - Article
VL - 62
SP - 216
EP - 222
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 3
ER -