The Pituitary Gland in the Laurence-Moon Syndrome

MICHAEL D. WHITAKER; BERND W. SCHEITHAUER; KALMAN T. KOVACS; RAYMOND V. RANDALL; R. JEAN CAMPBELL; HARUO OKAZAKI

doi:10.1016/S0025-6196(12)62445-8

The Pituitary Gland in the Laurence-Moon Syndrome

MICHAEL D. WHITAKER, BERND W. SCHEITHAUER, KALMAN T. KOVACS, RAYMOND V. RANDALL, R. JEAN CAMPBELL, HARUO OKAZAKI

Endocrinology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The apparent hypogonadism in patients with the Laurence-Moon syndrome has been variably attributed to unresponsiveness of target organs to gonadal hormones, primary end-organ failure, hypothalamic dysfunction, or pituitary failure. We report the first immunocytologic study of the pituitary gland in this rare disorder. No morphologic abnormalities were noted. The numbers and immunoreactivities of adenohypophyseal cell types were normal. No microscopic abnormalities were evident in the hypothalamus and target organs. The results of our study are consistent with recent biochemical data that suggest that pituitary function is normal in patients with this syndrome.

Original language	English (US)
Pages (from-to)	216-222
Number of pages	7
Journal	Mayo Clinic proceedings
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/S0025-6196(12)62445-8
State	Published - 1987

ASJC Scopus subject areas

Medicine(all)

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title = "The Pituitary Gland in the Laurence-Moon Syndrome",

abstract = "The apparent hypogonadism in patients with the Laurence-Moon syndrome has been variably attributed to unresponsiveness of target organs to gonadal hormones, primary end-organ failure, hypothalamic dysfunction, or pituitary failure. We report the first immunocytologic study of the pituitary gland in this rare disorder. No morphologic abnormalities were noted. The numbers and immunoreactivities of adenohypophyseal cell types were normal. No microscopic abnormalities were evident in the hypothalamus and target organs. The results of our study are consistent with recent biochemical data that suggest that pituitary function is normal in patients with this syndrome.",

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AU - WHITAKER, MICHAEL D.

AU - SCHEITHAUER, BERND W.

AU - KOVACS, KALMAN T.

AU - RANDALL, RAYMOND V.

AU - CAMPBELL, R. JEAN

AU - OKAZAKI, HARUO

PY - 1987

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AB - The apparent hypogonadism in patients with the Laurence-Moon syndrome has been variably attributed to unresponsiveness of target organs to gonadal hormones, primary end-organ failure, hypothalamic dysfunction, or pituitary failure. We report the first immunocytologic study of the pituitary gland in this rare disorder. No morphologic abnormalities were noted. The numbers and immunoreactivities of adenohypophyseal cell types were normal. No microscopic abnormalities were evident in the hypothalamus and target organs. The results of our study are consistent with recent biochemical data that suggest that pituitary function is normal in patients with this syndrome.

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