The Pituitary Gland in the Laurence-Moon Syndrome

MICHAEL D. WHITAKER, BERND W. SCHEITHAUER, KALMAN T. KOVACS, RAYMOND V. RANDALL, R. JEAN CAMPBELL, HARUO OKAZAKI

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5 Scopus citations

Abstract

The apparent hypogonadism in patients with the Laurence-Moon syndrome has been variably attributed to unresponsiveness of target organs to gonadal hormones, primary end-organ failure, hypothalamic dysfunction, or pituitary failure. We report the first immunocytologic study of the pituitary gland in this rare disorder. No morphologic abnormalities were noted. The numbers and immunoreactivities of adenohypophyseal cell types were normal. No microscopic abnormalities were evident in the hypothalamus and target organs. The results of our study are consistent with recent biochemical data that suggest that pituitary function is normal in patients with this syndrome.

Original languageEnglish (US)
Pages (from-to)216-222
Number of pages7
JournalMayo Clinic proceedings
Volume62
Issue number3
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Medicine(all)

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    WHITAKER, MICHAEL. D., SCHEITHAUER, BERND. W., KOVACS, KALMAN. T., RANDALL, RAYMOND. V., CAMPBELL, R. JEAN., & OKAZAKI, HARUO. (1987). The Pituitary Gland in the Laurence-Moon Syndrome. Mayo Clinic proceedings, 62(3), 216-222. https://doi.org/10.1016/S0025-6196(12)62445-8