The pituitary gland in the Laurence-Moon syndrome

M. D. Whitaker, B. W. Scheithauer, K. T. Kovacs, R. V. Randall, R. J. Campbell, H. Okazaki

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Abstract

The apparent hypogonadism in patients with the Laurence-Moon syndrome has been variably attributed to unresponsiveness of target organs to gonadal hormones, primary end-organ failure, hypothalamic dysfunction, or pituitary failure. We report the first immunocytologic study of the pituitary gland in this rare disorder. No morphological abnormalities were noted. The numbers and immunoreactivities of adenohypophyseal cell types were normal. No microscopic abnormalities were evident in the hypothalamus and target organs. The results of our study are consistent with recent biochemical data that suggest that pituitary function is normal in patients with this syndrome.

Original languageEnglish (US)
Pages (from-to)216-222
Number of pages7
JournalMayo Clinic Proceedings
Volume62
Issue number3
StatePublished - 1987

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Laurence-Moon Syndrome
Pituitary Gland
Gonadal Hormones
Hypogonadism
Hypothalamus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Whitaker, M. D., Scheithauer, B. W., Kovacs, K. T., Randall, R. V., Campbell, R. J., & Okazaki, H. (1987). The pituitary gland in the Laurence-Moon syndrome. Mayo Clinic Proceedings, 62(3), 216-222.

The pituitary gland in the Laurence-Moon syndrome. / Whitaker, M. D.; Scheithauer, B. W.; Kovacs, K. T.; Randall, R. V.; Campbell, R. J.; Okazaki, H.

In: Mayo Clinic Proceedings, Vol. 62, No. 3, 1987, p. 216-222.

Research output: Contribution to journalArticle

Whitaker, MD, Scheithauer, BW, Kovacs, KT, Randall, RV, Campbell, RJ & Okazaki, H 1987, 'The pituitary gland in the Laurence-Moon syndrome', Mayo Clinic Proceedings, vol. 62, no. 3, pp. 216-222.
Whitaker MD, Scheithauer BW, Kovacs KT, Randall RV, Campbell RJ, Okazaki H. The pituitary gland in the Laurence-Moon syndrome. Mayo Clinic Proceedings. 1987;62(3):216-222.
Whitaker, M. D. ; Scheithauer, B. W. ; Kovacs, K. T. ; Randall, R. V. ; Campbell, R. J. ; Okazaki, H. / The pituitary gland in the Laurence-Moon syndrome. In: Mayo Clinic Proceedings. 1987 ; Vol. 62, No. 3. pp. 216-222.
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