The piglet as an animal model for hypobaric hypoxia

J. Stepanek, D. Klocke, G. Malvin, Joseph E Parisi, H. Tazelaar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The objective of this study was to evaluate the piglet as a suitable animal model for human diseases of high altitude. We studied 12 piglets, 4- 10 weeks old, in a hypobaric chamber under conditions of high altitude at a pressure of 1/4 atmosphere (~320 Torr) for various periods of time (12, 24, 36, 48, and 72 hours) with continuous monitoring. The animals were decompressed every 24 hours for grooming and feeding. Two animals were studied as nonexposed controls, and one was studied as a control in the chamber without decompression. The animals were euthanized after the exposure, and a complete autopsy was performed. The tissues were then analyzed with light and electron microscopy. The animals all exhibited clinical features of ataxia, tachypnea with Cheyne-Stokes respiration, and lethargy. One animal vomited. The histologic and ultrastructural analysis showed normal organs, particularly lung and brain. The piglet may be a suitable animal model for the study of high altitude-related diseases in humans, but prolonged uninterrupted exposure and a delay in euthanasia after exposure to high altitude may be necessary for the development of reactive pathologic changes.

Original languageEnglish (US)
Pages (from-to)8-13
Number of pages6
JournalWilderness and Environmental Medicine
Volume9
Issue number1
StatePublished - 1998

Fingerprint

Animal Models
Cheyne-Stokes Respiration
Tachypnea
Animal Disease Models
Grooming
Lethargy
Euthanasia
Ataxia
Decompression
Atmosphere
Autopsy
Electron Microscopy
Hypoxia
Light
Pressure
Lung
Brain

Keywords

  • Animal model
  • Hypobaric hypoxia
  • Piglet

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine

Cite this

Stepanek, J., Klocke, D., Malvin, G., Parisi, J. E., & Tazelaar, H. (1998). The piglet as an animal model for hypobaric hypoxia. Wilderness and Environmental Medicine, 9(1), 8-13.

The piglet as an animal model for hypobaric hypoxia. / Stepanek, J.; Klocke, D.; Malvin, G.; Parisi, Joseph E; Tazelaar, H.

In: Wilderness and Environmental Medicine, Vol. 9, No. 1, 1998, p. 8-13.

Research output: Contribution to journalArticle

Stepanek, J, Klocke, D, Malvin, G, Parisi, JE & Tazelaar, H 1998, 'The piglet as an animal model for hypobaric hypoxia', Wilderness and Environmental Medicine, vol. 9, no. 1, pp. 8-13.
Stepanek J, Klocke D, Malvin G, Parisi JE, Tazelaar H. The piglet as an animal model for hypobaric hypoxia. Wilderness and Environmental Medicine. 1998;9(1):8-13.
Stepanek, J. ; Klocke, D. ; Malvin, G. ; Parisi, Joseph E ; Tazelaar, H. / The piglet as an animal model for hypobaric hypoxia. In: Wilderness and Environmental Medicine. 1998 ; Vol. 9, No. 1. pp. 8-13.
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