The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma

Heike Döppler, Ligia Bastea, Sahra Borges, Xochiquetzal Geiger, Peter Storz

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Vasodilator-stimulated phosphoprotein (VASP) signaling is critical for dynamic actin reorganization processes that define the motile phenotype of cells. Here we show that VASP is generally highly expressed in normal breast tissue and breast cancer. We also show that the phosphorylation status of VASP at S322 can be predictive for breast cancer progression to an aggressive phenotype. Our data indicate that phosphorylation at S322 is gradually decreased from normal breast to DCIS, luminal/ER+, HER2+ and basal-like/TN phenotypes. Similarly, the expression levels of PKD2, the kinase that phosphorylates VASP at this site, are decreased in invasive ductal carcinoma samples of all three groups. Overall, the phosphorylation status of this residue may serve as an indicator of aggressiveness of breast tumors.

Original languageEnglish (US)
Pages (from-to)29740-29752
Number of pages13
JournalOncotarget
Volume6
Issue number30
DOIs
StatePublished - 2015

Keywords

  • Breast cancer
  • Invasive
  • Phosphorylation
  • VASP

ASJC Scopus subject areas

  • Oncology

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