The pharmacotherapy of cirrhosis: concerns and proposed investigations and solutions

M. B. Hilscher, L. J. Odell, L. J. Myhre, L. Prokop, J. Talwalkar

Research output: Contribution to journalComment/debate

3 Scopus citations

Abstract

What is known and objective: The presence of cirrhosis has a multifaceted impact on hepatic drug metabolism. An area of concern and uncertainty in the care of patients with cirrhosis is the safe use of both prescription and over-the-counter medications. Comment: Retrospective studies indicate a high incidence of adverse drug reactions (ADRs) among patients with cirrhosis related to use of certain medication classes including angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and non-steroidal anti-inflammatory drugs. Conversely, use of appropriate medications, such as statins, may be decreased in this population due to fear of precipitating hepatotoxicity. What is new and conclusion: Pharmacotherapy in cirrhosis is an area of uncertainty and heterogeneity in clinical practice. Prescribing and dosing guidelines are needed to decrease the risk of serious ADRs in this high-risk patient population.

Original languageEnglish (US)
Pages (from-to)587-591
Number of pages5
JournalJournal of Clinical Pharmacy and Therapeutics
Volume41
Issue number6
DOIs
StatePublished - Dec 1 2016

Keywords

  • drug interaction
  • liver
  • pharmacists

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'The pharmacotherapy of cirrhosis: concerns and proposed investigations and solutions'. Together they form a unique fingerprint.

  • Cite this