The pharmacology of antidepressants at the synapse: Focus on newer compounds

E. Richelson; S. H. Preskorn; S. P. Roose; J. P. Feighner; L. A. Cunningham; W. C. Drevets

The pharmacology of antidepressants at the synapse: Focus on newer compounds

E. Richelson, S. H. Preskorn, S. P. Roose, J. P. Feighner, L. A. Cunningham, W. C. Drevets

Neuroscience

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

This paper reviews the in vitro effects of antidepressants on blockade of uptake of norepinephrine, serotonin, and dopamine at the synapse (rat synaptosomal preparations), as well as blockade of histamine H₁, muscarinic, α₁-adrenergic, and dopamine D₂ receptors in human brain tissue. The potency of an antidepressant at this blockade is predictive of the likelihood of its causing certain side effects and drug-drug interactions.

Original language	English (US)
Pages (from-to)	34-41
Number of pages	8
Journal	Journal of Clinical Psychiatry
Volume	55
Issue number	9 SUPPL. A
State	Published - 1994

ASJC Scopus subject areas

Psychiatry and Mental health

Cite this

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AU - Cunningham, L. A.

AU - Drevets, W. C.

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The pharmacology of antidepressants at the synapse: Focus on newer compounds

Abstract

ASJC Scopus subject areas

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