The pharmacology of antidepressants at the synapse: Focus on newer compounds

E. Richelson, S. H. Preskorn, S. P. Roose, J. P. Feighner, L. A. Cunningham, W. C. Drevets

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Abstract

This paper reviews the in vitro effects of antidepressants on blockade of uptake of norepinephrine, serotonin, and dopamine at the synapse (rat synaptosomal preparations), as well as blockade of histamine H1, muscarinic, α1-adrenergic, and dopamine D2 receptors in human brain tissue. The potency of an antidepressant at this blockade is predictive of the likelihood of its causing certain side effects and drug-drug interactions.

Original languageEnglish (US)
Pages (from-to)34-41
Number of pages8
JournalJournal of Clinical Psychiatry
Volume55
Issue number9 SUPPL. A
StatePublished - 1994

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ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Richelson, E., Preskorn, S. H., Roose, S. P., Feighner, J. P., Cunningham, L. A., & Drevets, W. C. (1994). The pharmacology of antidepressants at the synapse: Focus on newer compounds. Journal of Clinical Psychiatry, 55(9 SUPPL. A), 34-41.