The Peripheral Neuropathies of POEMS Syndrome and Castleman Disease

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes (POEMS) syndrome is a rare paraneoplastic disorder. The polyneuropathy can be the presenting symptom and is typically a painful, motor-predominant polyradiculoneuropathy often mimicking chronic inflammatory demyelinating polyradiculoneuropathy. The presence of a lambda monoclonal protein, elevated vascular endothelial growth factor, systemic features, and treatment resistance are clues to the diagnosis. Castleman disease (CD) is seen in a subset of these patients, and when present the neuropathy is similar but less severe. In contrast, in those patients with purely CD, the neuropathy is often a mild, painless distal sensory neuropathy.

Original languageEnglish (US)
Pages (from-to)153-163
Number of pages11
JournalHematology/Oncology Clinics of North America
Volume32
Issue number1
DOIs
StatePublished - Feb 1 2018

Keywords

  • Castleman disease
  • Castleman neuropathy
  • Monoclonal gammopathy
  • POEMS neuropathy
  • POEMS syndrome

ASJC Scopus subject areas

  • Hematology
  • Oncology

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