The pattern of genomic gains in salivary gland MALT lymphomas

Yuanping Zhou; Hongtao Ye; Jose I. Martin-Subero; Stefan Gesk; Rifat Hamoudi; Yong Jie Lu; Rubin Wang; Janet Shipley; Reiner Siebert; Peter G. Isaacson; Ahmet Dogan; Ming Qing Du

doi:10.3324/haematol.10191

The pattern of genomic gains in salivary gland MALT lymphomas

Yuanping Zhou, Hongtao Ye, Jose I. Martin-Subero, Stefan Gesk, Rifat Hamoudi, Yong Jie Lu, Rubin Wang, Janet Shipley, Reiner Siebert, Peter G. Isaacson, Ahmet Dogan, Ming Qing Du

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Background and Objectives: Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas typically lack chromosomal translocations and the molecular genetics underlying their development is unknown. The aim of this study was to investigate chromosomal changes in these lymphomas. Design and Methods: We performed comparative genomic hybridisation using DNA samples extracted from microdissected tumour cells in 19 salivary gland MALT lymphomas. Recurrent chromosomal changes were further verified by interphase fluorescence in situ hybridization (FISH). Results: Chromosomal gains were much more common than losses. Recurrent gains were found at 1p32-ter (42%), 9q33-34 (84%), 11q11-13 (42%), 17 (58%) and 18q21-22 (42%). Among these, the recurrent gains at 9q34, 11q11-13 and 18q21 were nearly the exclusive gain of the corresponding chromosome. Notably, chromosomal gains at 9q34, 11q13 and 18q21 were frequently concurrent, with 12/19 cases affecting at least two of the three loci. The genomic gains at these chromosomal regions were further confirmed by interphase FISH with probes targeting the TRAF2 and CARD9 (9q34), RELA and CCND1 (11q13), and MALT1 (18q21) loci. Interpretation and Conclusions: Salivary gland MALT lymphomas show a conserved pattern of chromosomal gains, which appear to target genes positively modulating cell survival and proliferation.

Original language	English (US)
Pages (from-to)	921-927
Number of pages	7
Journal	Haematologica
Volume	92
Issue number	7
DOIs	https://doi.org/10.3324/haematol.10191
State	Published - Jul 2007

Keywords

CGH
MALT lymphoma
Salivary gland

ASJC Scopus subject areas

Hematology

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10.3324/haematol.10191

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title = "The pattern of genomic gains in salivary gland MALT lymphomas",

abstract = "Background and Objectives: Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas typically lack chromosomal translocations and the molecular genetics underlying their development is unknown. The aim of this study was to investigate chromosomal changes in these lymphomas. Design and Methods: We performed comparative genomic hybridisation using DNA samples extracted from microdissected tumour cells in 19 salivary gland MALT lymphomas. Recurrent chromosomal changes were further verified by interphase fluorescence in situ hybridization (FISH). Results: Chromosomal gains were much more common than losses. Recurrent gains were found at 1p32-ter (42%), 9q33-34 (84%), 11q11-13 (42%), 17 (58%) and 18q21-22 (42%). Among these, the recurrent gains at 9q34, 11q11-13 and 18q21 were nearly the exclusive gain of the corresponding chromosome. Notably, chromosomal gains at 9q34, 11q13 and 18q21 were frequently concurrent, with 12/19 cases affecting at least two of the three loci. The genomic gains at these chromosomal regions were further confirmed by interphase FISH with probes targeting the TRAF2 and CARD9 (9q34), RELA and CCND1 (11q13), and MALT1 (18q21) loci. Interpretation and Conclusions: Salivary gland MALT lymphomas show a conserved pattern of chromosomal gains, which appear to target genes positively modulating cell survival and proliferation.",

keywords = "CGH, MALT lymphoma, Salivary gland",

author = "Yuanping Zhou and Hongtao Ye and Martin-Subero, {Jose I.} and Stefan Gesk and Rifat Hamoudi and Lu, {Yong Jie} and Rubin Wang and Janet Shipley and Reiner Siebert and Isaacson, {Peter G.} and Ahmet Dogan and Du, {Ming Qing}",

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doi = "10.3324/haematol.10191",

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AU - Zhou, Yuanping

AU - Ye, Hongtao

AU - Martin-Subero, Jose I.

AU - Gesk, Stefan

AU - Hamoudi, Rifat

AU - Lu, Yong Jie

AU - Wang, Rubin

AU - Shipley, Janet

AU - Siebert, Reiner

AU - Isaacson, Peter G.

AU - Dogan, Ahmet

AU - Du, Ming Qing

PY - 2007/7

Y1 - 2007/7

N2 - Background and Objectives: Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas typically lack chromosomal translocations and the molecular genetics underlying their development is unknown. The aim of this study was to investigate chromosomal changes in these lymphomas. Design and Methods: We performed comparative genomic hybridisation using DNA samples extracted from microdissected tumour cells in 19 salivary gland MALT lymphomas. Recurrent chromosomal changes were further verified by interphase fluorescence in situ hybridization (FISH). Results: Chromosomal gains were much more common than losses. Recurrent gains were found at 1p32-ter (42%), 9q33-34 (84%), 11q11-13 (42%), 17 (58%) and 18q21-22 (42%). Among these, the recurrent gains at 9q34, 11q11-13 and 18q21 were nearly the exclusive gain of the corresponding chromosome. Notably, chromosomal gains at 9q34, 11q13 and 18q21 were frequently concurrent, with 12/19 cases affecting at least two of the three loci. The genomic gains at these chromosomal regions were further confirmed by interphase FISH with probes targeting the TRAF2 and CARD9 (9q34), RELA and CCND1 (11q13), and MALT1 (18q21) loci. Interpretation and Conclusions: Salivary gland MALT lymphomas show a conserved pattern of chromosomal gains, which appear to target genes positively modulating cell survival and proliferation.

AB - Background and Objectives: Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas typically lack chromosomal translocations and the molecular genetics underlying their development is unknown. The aim of this study was to investigate chromosomal changes in these lymphomas. Design and Methods: We performed comparative genomic hybridisation using DNA samples extracted from microdissected tumour cells in 19 salivary gland MALT lymphomas. Recurrent chromosomal changes were further verified by interphase fluorescence in situ hybridization (FISH). Results: Chromosomal gains were much more common than losses. Recurrent gains were found at 1p32-ter (42%), 9q33-34 (84%), 11q11-13 (42%), 17 (58%) and 18q21-22 (42%). Among these, the recurrent gains at 9q34, 11q11-13 and 18q21 were nearly the exclusive gain of the corresponding chromosome. Notably, chromosomal gains at 9q34, 11q13 and 18q21 were frequently concurrent, with 12/19 cases affecting at least two of the three loci. The genomic gains at these chromosomal regions were further confirmed by interphase FISH with probes targeting the TRAF2 and CARD9 (9q34), RELA and CCND1 (11q13), and MALT1 (18q21) loci. Interpretation and Conclusions: Salivary gland MALT lymphomas show a conserved pattern of chromosomal gains, which appear to target genes positively modulating cell survival and proliferation.

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KW - MALT lymphoma

KW - Salivary gland

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The pattern of genomic gains in salivary gland MALT lymphomas

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