The pathology of primary progressive multiple sclerosis

W. Brück, C. Lucchinetti, H. Lassmann

Research output: Contribution to journalReview article

71 Scopus citations

Abstract

The present review will focus on the current knowledge of the pathology of primary progressive multiple sclerosis lesions. Multiple sclerosis (MS) is an inflammatory demyelinating disease with a broad clinical variability. The main disease courses are relapsing-remitting, secondary progressive and primary progressive MS. Pathological studies examining the specific underlying pathology of a defined clinical subtype are rare. Here, we focus on the pathological characteristics of the MS lesions and summarize the current findings of the pathology of primary progressive MS with respect to inflammation, oligodendrocyte/myelin pathology, axon destruction and immunopathology of the lesions.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalMultiple Sclerosis
Volume8
Issue number2
DOIs
StatePublished - Jan 1 2002

Keywords

  • Axons
  • Demyelination
  • Inflammation
  • Multiple sclerosis
  • Primary progressive

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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