TY - JOUR
T1 - The pathology of multiple sclerosis
T2 - evidence for heterogeneity.
AU - Morales, Yazmín
AU - Parisi, Joseph E.
AU - Lucchinetti, Claudia F.
PY - 2006
Y1 - 2006
N2 - The idiopathic inflammatory demyelinating diseases (IIDDs) consist of a broad spectrum of disorders that vary in their clinical course, regional distribution, and pathology. Though pathology of these demyelinating disorders demonstrates extensive interindividual heterogeneity, there is notable homogeneity within individual patients. The relation between the diverse underlying pathology of IIDDs and the various clinical, paraclinical, and radiological findings is unclear. Finding less-invasive clinical or paraclinical surrogate markers, which accurately and reliably predict the underlying distinct pathologies within the family of IIDDs, can potentially guide future therapies that better target specific pathogenic mechanisms.
AB - The idiopathic inflammatory demyelinating diseases (IIDDs) consist of a broad spectrum of disorders that vary in their clinical course, regional distribution, and pathology. Though pathology of these demyelinating disorders demonstrates extensive interindividual heterogeneity, there is notable homogeneity within individual patients. The relation between the diverse underlying pathology of IIDDs and the various clinical, paraclinical, and radiological findings is unclear. Finding less-invasive clinical or paraclinical surrogate markers, which accurately and reliably predict the underlying distinct pathologies within the family of IIDDs, can potentially guide future therapies that better target specific pathogenic mechanisms.
UR - http://www.scopus.com/inward/record.url?scp=33644840029&partnerID=8YFLogxK
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M3 - Review article
C2 - 16400825
AN - SCOPUS:33644840029
SN - 0091-3952
VL - 98
SP - 27
EP - 45
JO - Advances in neurology
JF - Advances in neurology
ER -