The pathology of large-vessel vasculitides

Dylan V. Miller, Joseph Maleszewski

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Vasculitis affecting large elastic arteries, including the aorta and major proximal branches, encompasses various diseases including Takayasu arteritis, giant cell (or temporal) arteritis, and tertiary syphilis, but also may occur as a rare complication of Behçet's disease, rheumatoid arthritis, sarcoidosis, Cogan syndrome, Kawasaki disease, ankylosing spondylitis, systemic lupus erythematosus and Wegener's granulomatosis. Recent reports have also established a link between inflammatory abdominal aortic aneurysm as well as lymphoplasmacytic thoracic aortitis with an overabundance of IgG4-producing plasma cells and the burgeoning constellation of "Hyper-IgG4" syndromes. This review focuses on morphologic aspects of large-vessel vasculitis pathology associated with giant cell arteritis, Takayasu arteritis, idiopathic or isolated aortitis, lymphoplasmacytic thoracic and ascending aortitis, and the inflammatory aneurysm/retroperitoneal fibrosis syndrome.

Original languageEnglish (US)
JournalClinical and Experimental Rheumatology
Volume29
Issue number1 SUPPL. 64
StatePublished - Jul 21 2011

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Aortitis
Vasculitis
Takayasu Arteritis
Giant Cell Arteritis
Pathology
Cogan Syndrome
Thorax
Immunoglobulin G
Retroperitoneal Fibrosis
Mucocutaneous Lymph Node Syndrome
Granulomatosis with Polyangiitis
Ankylosing Spondylitis
Abdominal Aortic Aneurysm
Giant Cells
Sarcoidosis
Plasma Cells
Systemic Lupus Erythematosus
Aneurysm
Aorta
Rheumatoid Arthritis

Keywords

  • Aortitis
  • Giant cell arteritis
  • IgG4
  • Takayasu

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

The pathology of large-vessel vasculitides. / Miller, Dylan V.; Maleszewski, Joseph.

In: Clinical and Experimental Rheumatology, Vol. 29, No. 1 SUPPL. 64, 21.07.2011.

Research output: Contribution to journalReview article

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