The pathology of interstitial lung disease in nylon flock workers

Alexander H. Boag, Thomas V. Colby, Armando E. Fraire, Charles Kuhn, Victor L. Roggli, William D. Travis, Val Vallyathan

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Flocking is a widely used industrial process in which short lengths of synthetic fibers are applied to backing fabric to produce plush material. In response to an apparent outbreak of interstitial lung disease in flock workers, the Centers for Disease Control hosted a clinical pathological workshop to identify the defining characteristics of the disease and possible etiologic agents. Six pathologists reviewed 15 biopsies of 15 cases (out of a clinical caseload of 20 patients) and assessed the pattern, extent and degree of pulmonary inflammation, fibrosis, and other changes. A consensus clinical- pathologic diagnosis was reached for each patient and correlated with clinical and radiologic findings. Four of eight open lung biopsies and one of seven closed (transbronchial) lung biopsies demonstrated a characteristic pattern to which the descriptive terminology lymphocytic bronchiolitis and peribronchiolitis with lymphoid hyperplasia was applied. The other biopsies showed nonspecific inflammatory changes, airspace organization, and diffuse alveolar damage. One open lung biopsy demonstrated respiratory bronchiolitis with lymphoid hyperplasia. None of the lung biopsies showed more than mild interstitial fibrosis and no granulomas were identified. The consensus of the workshop was that lymphocytic bronchiolitis and peribronchiolitis with lymphoid hyperplasia was a characteristic and distinctive pattern of injury in the flock workers' lung biopsies. Although the etiology of this disease remains undefined at present, the injury pattern and environmental studies suggest a chronic immunologic response to inhaled material.

Original languageEnglish (US)
Pages (from-to)1539-1545
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume23
Issue number12
DOIs
StatePublished - Dec 1999

Fingerprint

Nylons
Interstitial Lung Diseases
Pathology
Biopsy
Bronchiolitis
Lung
Hyperplasia
Consensus Development Conferences
Pulmonary Fibrosis
Wounds and Injuries
Centers for Disease Control and Prevention (U.S.)
Granuloma
Terminology
Disease Outbreaks
Pneumonia
Fibrosis
Organizations
Education

Keywords

  • Flock
  • Interstitial lung disease
  • Lymphocytic bronchiolitis
  • Lymphoid hyperplasia
  • Nylon
  • Occupational exposure

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Boag, A. H., Colby, T. V., Fraire, A. E., Kuhn, C., Roggli, V. L., Travis, W. D., & Vallyathan, V. (1999). The pathology of interstitial lung disease in nylon flock workers. American Journal of Surgical Pathology, 23(12), 1539-1545. https://doi.org/10.1097/00000478-199912000-00012

The pathology of interstitial lung disease in nylon flock workers. / Boag, Alexander H.; Colby, Thomas V.; Fraire, Armando E.; Kuhn, Charles; Roggli, Victor L.; Travis, William D.; Vallyathan, Val.

In: American Journal of Surgical Pathology, Vol. 23, No. 12, 12.1999, p. 1539-1545.

Research output: Contribution to journalArticle

Boag, AH, Colby, TV, Fraire, AE, Kuhn, C, Roggli, VL, Travis, WD & Vallyathan, V 1999, 'The pathology of interstitial lung disease in nylon flock workers', American Journal of Surgical Pathology, vol. 23, no. 12, pp. 1539-1545. https://doi.org/10.1097/00000478-199912000-00012
Boag, Alexander H. ; Colby, Thomas V. ; Fraire, Armando E. ; Kuhn, Charles ; Roggli, Victor L. ; Travis, William D. ; Vallyathan, Val. / The pathology of interstitial lung disease in nylon flock workers. In: American Journal of Surgical Pathology. 1999 ; Vol. 23, No. 12. pp. 1539-1545.
@article{369a8a4b770c42e4b92fceadac288ca9,
title = "The pathology of interstitial lung disease in nylon flock workers",
abstract = "Flocking is a widely used industrial process in which short lengths of synthetic fibers are applied to backing fabric to produce plush material. In response to an apparent outbreak of interstitial lung disease in flock workers, the Centers for Disease Control hosted a clinical pathological workshop to identify the defining characteristics of the disease and possible etiologic agents. Six pathologists reviewed 15 biopsies of 15 cases (out of a clinical caseload of 20 patients) and assessed the pattern, extent and degree of pulmonary inflammation, fibrosis, and other changes. A consensus clinical- pathologic diagnosis was reached for each patient and correlated with clinical and radiologic findings. Four of eight open lung biopsies and one of seven closed (transbronchial) lung biopsies demonstrated a characteristic pattern to which the descriptive terminology lymphocytic bronchiolitis and peribronchiolitis with lymphoid hyperplasia was applied. The other biopsies showed nonspecific inflammatory changes, airspace organization, and diffuse alveolar damage. One open lung biopsy demonstrated respiratory bronchiolitis with lymphoid hyperplasia. None of the lung biopsies showed more than mild interstitial fibrosis and no granulomas were identified. The consensus of the workshop was that lymphocytic bronchiolitis and peribronchiolitis with lymphoid hyperplasia was a characteristic and distinctive pattern of injury in the flock workers' lung biopsies. Although the etiology of this disease remains undefined at present, the injury pattern and environmental studies suggest a chronic immunologic response to inhaled material.",
keywords = "Flock, Interstitial lung disease, Lymphocytic bronchiolitis, Lymphoid hyperplasia, Nylon, Occupational exposure",
author = "Boag, {Alexander H.} and Colby, {Thomas V.} and Fraire, {Armando E.} and Charles Kuhn and Roggli, {Victor L.} and Travis, {William D.} and Val Vallyathan",
year = "1999",
month = "12",
doi = "10.1097/00000478-199912000-00012",
language = "English (US)",
volume = "23",
pages = "1539--1545",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - The pathology of interstitial lung disease in nylon flock workers

AU - Boag, Alexander H.

AU - Colby, Thomas V.

AU - Fraire, Armando E.

AU - Kuhn, Charles

AU - Roggli, Victor L.

AU - Travis, William D.

AU - Vallyathan, Val

PY - 1999/12

Y1 - 1999/12

N2 - Flocking is a widely used industrial process in which short lengths of synthetic fibers are applied to backing fabric to produce plush material. In response to an apparent outbreak of interstitial lung disease in flock workers, the Centers for Disease Control hosted a clinical pathological workshop to identify the defining characteristics of the disease and possible etiologic agents. Six pathologists reviewed 15 biopsies of 15 cases (out of a clinical caseload of 20 patients) and assessed the pattern, extent and degree of pulmonary inflammation, fibrosis, and other changes. A consensus clinical- pathologic diagnosis was reached for each patient and correlated with clinical and radiologic findings. Four of eight open lung biopsies and one of seven closed (transbronchial) lung biopsies demonstrated a characteristic pattern to which the descriptive terminology lymphocytic bronchiolitis and peribronchiolitis with lymphoid hyperplasia was applied. The other biopsies showed nonspecific inflammatory changes, airspace organization, and diffuse alveolar damage. One open lung biopsy demonstrated respiratory bronchiolitis with lymphoid hyperplasia. None of the lung biopsies showed more than mild interstitial fibrosis and no granulomas were identified. The consensus of the workshop was that lymphocytic bronchiolitis and peribronchiolitis with lymphoid hyperplasia was a characteristic and distinctive pattern of injury in the flock workers' lung biopsies. Although the etiology of this disease remains undefined at present, the injury pattern and environmental studies suggest a chronic immunologic response to inhaled material.

AB - Flocking is a widely used industrial process in which short lengths of synthetic fibers are applied to backing fabric to produce plush material. In response to an apparent outbreak of interstitial lung disease in flock workers, the Centers for Disease Control hosted a clinical pathological workshop to identify the defining characteristics of the disease and possible etiologic agents. Six pathologists reviewed 15 biopsies of 15 cases (out of a clinical caseload of 20 patients) and assessed the pattern, extent and degree of pulmonary inflammation, fibrosis, and other changes. A consensus clinical- pathologic diagnosis was reached for each patient and correlated with clinical and radiologic findings. Four of eight open lung biopsies and one of seven closed (transbronchial) lung biopsies demonstrated a characteristic pattern to which the descriptive terminology lymphocytic bronchiolitis and peribronchiolitis with lymphoid hyperplasia was applied. The other biopsies showed nonspecific inflammatory changes, airspace organization, and diffuse alveolar damage. One open lung biopsy demonstrated respiratory bronchiolitis with lymphoid hyperplasia. None of the lung biopsies showed more than mild interstitial fibrosis and no granulomas were identified. The consensus of the workshop was that lymphocytic bronchiolitis and peribronchiolitis with lymphoid hyperplasia was a characteristic and distinctive pattern of injury in the flock workers' lung biopsies. Although the etiology of this disease remains undefined at present, the injury pattern and environmental studies suggest a chronic immunologic response to inhaled material.

KW - Flock

KW - Interstitial lung disease

KW - Lymphocytic bronchiolitis

KW - Lymphoid hyperplasia

KW - Nylon

KW - Occupational exposure

UR - http://www.scopus.com/inward/record.url?scp=0032750434&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032750434&partnerID=8YFLogxK

U2 - 10.1097/00000478-199912000-00012

DO - 10.1097/00000478-199912000-00012

M3 - Article

C2 - 10584708

AN - SCOPUS:0032750434

VL - 23

SP - 1539

EP - 1545

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 12

ER -