TY - JOUR
T1 - The pathogenesis of hepatitis C virus is influenced by cytomegalovirus
AU - Razonable, Raymund R.
AU - Burak, Kelly W.
AU - Van Cruijsen, Hester
AU - Brown, Robert A.
AU - Charlton, Michael R.
AU - Smith, Thomas F.
AU - Espy, Mark J.
AU - Kremers, Walter
AU - Wilson, Jennie A.
AU - Groettum, Cynthia
AU - Wiesner, Russell
AU - Paya, Carlos V.
N1 - Funding Information:
Financial support: H.v.C. was a visiting medical student from the University of Groningen, The Netherlands, and was supported by the Foundation of Jan Kornelis de Cock Stichting during the conduct of this project. K.B. was supported by the American Association for the Study of Liver Disease/Schering Advanced Hepatology Fellowship.
PY - 2002/10/15
Y1 - 2002/10/15
N2 - We investigated the effect of β-herpesviruses on allograft failure and mortality, hepatitis C virus (HCV) replication, and liver histologic characteristics among 92 HCV-infected liver transplant recipients. Reactivation of cytomegalovirus (CMV) but not of human herpesvirus 6 (HHV-6) was independently associated with allograft failure and mortality (risk ratio, 3.71; 95% confidence interval, 1.64-8.39); allograft failure and mortality was observed in 48% of patients with CMV disease, 35% of patients with subclinical CMV infection, and 17% of patients without CMV infection (P = .0275). CMV reactivation was highly predictive of mortality (P>.001), regardless of whether it remained subclinical or evolved into CMV disease. Patients with CMV disease had a higher fibrosis stage (P = .05) and had a trend toward a higher hepatitis activity index (P = .10) and HCV load (P = .10) at 16 weeks after liver transplantation. The pathogenesis of HCV is influenced by its interaction with CMV but not with HHV-6.
AB - We investigated the effect of β-herpesviruses on allograft failure and mortality, hepatitis C virus (HCV) replication, and liver histologic characteristics among 92 HCV-infected liver transplant recipients. Reactivation of cytomegalovirus (CMV) but not of human herpesvirus 6 (HHV-6) was independently associated with allograft failure and mortality (risk ratio, 3.71; 95% confidence interval, 1.64-8.39); allograft failure and mortality was observed in 48% of patients with CMV disease, 35% of patients with subclinical CMV infection, and 17% of patients without CMV infection (P = .0275). CMV reactivation was highly predictive of mortality (P>.001), regardless of whether it remained subclinical or evolved into CMV disease. Patients with CMV disease had a higher fibrosis stage (P = .05) and had a trend toward a higher hepatitis activity index (P = .10) and HCV load (P = .10) at 16 weeks after liver transplantation. The pathogenesis of HCV is influenced by its interaction with CMV but not with HHV-6.
UR - http://www.scopus.com/inward/record.url?scp=0037108614&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037108614&partnerID=8YFLogxK
U2 - 10.1086/342911
DO - 10.1086/342911
M3 - Article
C2 - 12355385
AN - SCOPUS:0037108614
VL - 35
SP - 974
EP - 981
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 8
ER -