The pathogenesis of hepatitis C virus is influenced by cytomegalovirus

Raymund R Razonable, Kelly W. Burak, Hester Van Cruijsen, Robert A. Brown, Michael R. Charlton, Thomas F. Smith, Mark J. Espy, Walter K Kremers, Jennie A. Wilson, Cynthia Groettum, Russell Wiesner, Carlos V. Paya

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Abstract

We investigated the effect of β-herpesviruses on allograft failure and mortality, hepatitis C virus (HCV) replication, and liver histologic characteristics among 92 HCV-infected liver transplant recipients. Reactivation of cytomegalovirus (CMV) but not of human herpesvirus 6 (HHV-6) was independently associated with allograft failure and mortality (risk ratio, 3.71; 95% confidence interval, 1.64-8.39); allograft failure and mortality was observed in 48% of patients with CMV disease, 35% of patients with subclinical CMV infection, and 17% of patients without CMV infection (P = .0275). CMV reactivation was highly predictive of mortality (P<.001), regardless of whether it remained subclinical or evolved into CMV disease. Patients with CMV disease had a higher fibrosis stage (P = .05) and had a trend toward a higher hepatitis activity index (P = .10) and HCV load (P = .10) at 16 weeks after liver transplantation. The pathogenesis of HCV is influenced by its interaction with CMV but not with HHV-6.

Original languageEnglish (US)
Pages (from-to)974-981
Number of pages8
JournalClinical Infectious Diseases
Volume35
Issue number8
DOIs
StatePublished - Oct 15 2002

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Cytomegalovirus
Hepacivirus
Allografts
Human Herpesvirus 6
Mortality
Cytomegalovirus Infections
Asymptomatic Infections
Herpesviridae
Liver
Virus Replication
Liver Transplantation
Hepatitis
Fibrosis
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Immunology

Cite this

Razonable, R. R., Burak, K. W., Van Cruijsen, H., Brown, R. A., Charlton, M. R., Smith, T. F., ... Paya, C. V. (2002). The pathogenesis of hepatitis C virus is influenced by cytomegalovirus. Clinical Infectious Diseases, 35(8), 974-981. https://doi.org/10.1086/342911

The pathogenesis of hepatitis C virus is influenced by cytomegalovirus. / Razonable, Raymund R; Burak, Kelly W.; Van Cruijsen, Hester; Brown, Robert A.; Charlton, Michael R.; Smith, Thomas F.; Espy, Mark J.; Kremers, Walter K; Wilson, Jennie A.; Groettum, Cynthia; Wiesner, Russell; Paya, Carlos V.

In: Clinical Infectious Diseases, Vol. 35, No. 8, 15.10.2002, p. 974-981.

Research output: Contribution to journalArticle

Razonable, RR, Burak, KW, Van Cruijsen, H, Brown, RA, Charlton, MR, Smith, TF, Espy, MJ, Kremers, WK, Wilson, JA, Groettum, C, Wiesner, R & Paya, CV 2002, 'The pathogenesis of hepatitis C virus is influenced by cytomegalovirus', Clinical Infectious Diseases, vol. 35, no. 8, pp. 974-981. https://doi.org/10.1086/342911
Razonable RR, Burak KW, Van Cruijsen H, Brown RA, Charlton MR, Smith TF et al. The pathogenesis of hepatitis C virus is influenced by cytomegalovirus. Clinical Infectious Diseases. 2002 Oct 15;35(8):974-981. https://doi.org/10.1086/342911
Razonable, Raymund R ; Burak, Kelly W. ; Van Cruijsen, Hester ; Brown, Robert A. ; Charlton, Michael R. ; Smith, Thomas F. ; Espy, Mark J. ; Kremers, Walter K ; Wilson, Jennie A. ; Groettum, Cynthia ; Wiesner, Russell ; Paya, Carlos V. / The pathogenesis of hepatitis C virus is influenced by cytomegalovirus. In: Clinical Infectious Diseases. 2002 ; Vol. 35, No. 8. pp. 974-981.
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