The pathogenesis of hepatitis C virus is influenced by cytomegalovirus

Raymund R. Razonable; Kelly W. Burak; Hester Van Cruijsen; Robert A. Brown; Michael R. Charlton; Thomas F. Smith; Mark J. Espy; Walter Kremers; Jennie A. Wilson; Cynthia Groettum; Russell Wiesner; Carlos V. Paya

doi:10.1086/342911

The pathogenesis of hepatitis C virus is influenced by cytomegalovirus

Raymund R. Razonable, Kelly W. Burak, Hester Van Cruijsen, Robert A. Brown, Michael R. Charlton, Thomas F. Smith, Mark J. Espy, Walter Kremers, Jennie A. Wilson, Cynthia Groettum, Russell Wiesner, Carlos V. Paya

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

We investigated the effect of β-herpesviruses on allograft failure and mortality, hepatitis C virus (HCV) replication, and liver histologic characteristics among 92 HCV-infected liver transplant recipients. Reactivation of cytomegalovirus (CMV) but not of human herpesvirus 6 (HHV-6) was independently associated with allograft failure and mortality (risk ratio, 3.71; 95% confidence interval, 1.64-8.39); allograft failure and mortality was observed in 48% of patients with CMV disease, 35% of patients with subclinical CMV infection, and 17% of patients without CMV infection (P = .0275). CMV reactivation was highly predictive of mortality (P>.001), regardless of whether it remained subclinical or evolved into CMV disease. Patients with CMV disease had a higher fibrosis stage (P = .05) and had a trend toward a higher hepatitis activity index (P = .10) and HCV load (P = .10) at 16 weeks after liver transplantation. The pathogenesis of HCV is influenced by its interaction with CMV but not with HHV-6.

Original language	English (US)
Pages (from-to)	974-981
Number of pages	8
Journal	Clinical Infectious Diseases
Volume	35
Issue number	8
DOIs	https://doi.org/10.1086/342911
State	Published - Oct 15 2002

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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The pathogenesis of hepatitis C virus is influenced by cytomegalovirus. / Razonable, Raymund R.; Burak, Kelly W.; Van Cruijsen, Hester; Brown, Robert A.; Charlton, Michael R.; Smith, Thomas F.; Espy, Mark J.; Kremers, Walter; Wilson, Jennie A.; Groettum, Cynthia; Wiesner, Russell; Paya, Carlos V.

In: Clinical Infectious Diseases, Vol. 35, No. 8, 15.10.2002, p. 974-981.

Research output: Contribution to journal › Article › peer-review

Razonable, Raymund R. ; Burak, Kelly W. ; Van Cruijsen, Hester ; Brown, Robert A. ; Charlton, Michael R. ; Smith, Thomas F. ; Espy, Mark J. ; Kremers, Walter ; Wilson, Jennie A. ; Groettum, Cynthia ; Wiesner, Russell ; Paya, Carlos V. / The pathogenesis of hepatitis C virus is influenced by cytomegalovirus. In: Clinical Infectious Diseases. 2002 ; Vol. 35, No. 8. pp. 974-981.

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abstract = "We investigated the effect of β-herpesviruses on allograft failure and mortality, hepatitis C virus (HCV) replication, and liver histologic characteristics among 92 HCV-infected liver transplant recipients. Reactivation of cytomegalovirus (CMV) but not of human herpesvirus 6 (HHV-6) was independently associated with allograft failure and mortality (risk ratio, 3.71; 95% confidence interval, 1.64-8.39); allograft failure and mortality was observed in 48% of patients with CMV disease, 35% of patients with subclinical CMV infection, and 17% of patients without CMV infection (P = .0275). CMV reactivation was highly predictive of mortality (P>.001), regardless of whether it remained subclinical or evolved into CMV disease. Patients with CMV disease had a higher fibrosis stage (P = .05) and had a trend toward a higher hepatitis activity index (P = .10) and HCV load (P = .10) at 16 weeks after liver transplantation. The pathogenesis of HCV is influenced by its interaction with CMV but not with HHV-6.",

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