The pathobiology of biliary epithelia

S. K. Roberts, J. Ludwig, Nicholas F La Russo

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Our understanding of the pathobiology of biliary epithelia is rapidly growing because of a surge of investigative activity. This became possible after suitable experimental models and techniques were developed with which to study cholangiocyte biology. Although the molecular mechanisms of bile formation by cholangiocytes and the role of these cells as a major cellular target in a variety of severe hepatobiliary diseases are currently being investigated, many questions remain unanswered, particularly regarding cholangiocellular functions, both in normal and abnormal conditions. As current experimental models become more refined, scientists with interests as diverse as cell biology and physiology, morphology, pharmacology, immunology, genetics, and oncology can be expected to further clarify the pathobiology of biliary epithelia.

Original languageEnglish (US)
Pages (from-to)269-279
Number of pages11
JournalGastroenterology
Volume112
Issue number1
StatePublished - 1997

Fingerprint

Theoretical Models
Epithelium
Cell Physiological Phenomena
Allergy and Immunology
Bile
Cell Biology
Pharmacology

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Roberts, S. K., Ludwig, J., & La Russo, N. F. (1997). The pathobiology of biliary epithelia. Gastroenterology, 112(1), 269-279.

The pathobiology of biliary epithelia. / Roberts, S. K.; Ludwig, J.; La Russo, Nicholas F.

In: Gastroenterology, Vol. 112, No. 1, 1997, p. 269-279.

Research output: Contribution to journalArticle

Roberts, SK, Ludwig, J & La Russo, NF 1997, 'The pathobiology of biliary epithelia', Gastroenterology, vol. 112, no. 1, pp. 269-279.
Roberts SK, Ludwig J, La Russo NF. The pathobiology of biliary epithelia. Gastroenterology. 1997;112(1):269-279.
Roberts, S. K. ; Ludwig, J. ; La Russo, Nicholas F. / The pathobiology of biliary epithelia. In: Gastroenterology. 1997 ; Vol. 112, No. 1. pp. 269-279.
@article{7b098490d53740a9a6d63531cc04ffd2,
title = "The pathobiology of biliary epithelia",
abstract = "Our understanding of the pathobiology of biliary epithelia is rapidly growing because of a surge of investigative activity. This became possible after suitable experimental models and techniques were developed with which to study cholangiocyte biology. Although the molecular mechanisms of bile formation by cholangiocytes and the role of these cells as a major cellular target in a variety of severe hepatobiliary diseases are currently being investigated, many questions remain unanswered, particularly regarding cholangiocellular functions, both in normal and abnormal conditions. As current experimental models become more refined, scientists with interests as diverse as cell biology and physiology, morphology, pharmacology, immunology, genetics, and oncology can be expected to further clarify the pathobiology of biliary epithelia.",
author = "Roberts, {S. K.} and J. Ludwig and {La Russo}, {Nicholas F}",
year = "1997",
language = "English (US)",
volume = "112",
pages = "269--279",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - The pathobiology of biliary epithelia

AU - Roberts, S. K.

AU - Ludwig, J.

AU - La Russo, Nicholas F

PY - 1997

Y1 - 1997

N2 - Our understanding of the pathobiology of biliary epithelia is rapidly growing because of a surge of investigative activity. This became possible after suitable experimental models and techniques were developed with which to study cholangiocyte biology. Although the molecular mechanisms of bile formation by cholangiocytes and the role of these cells as a major cellular target in a variety of severe hepatobiliary diseases are currently being investigated, many questions remain unanswered, particularly regarding cholangiocellular functions, both in normal and abnormal conditions. As current experimental models become more refined, scientists with interests as diverse as cell biology and physiology, morphology, pharmacology, immunology, genetics, and oncology can be expected to further clarify the pathobiology of biliary epithelia.

AB - Our understanding of the pathobiology of biliary epithelia is rapidly growing because of a surge of investigative activity. This became possible after suitable experimental models and techniques were developed with which to study cholangiocyte biology. Although the molecular mechanisms of bile formation by cholangiocytes and the role of these cells as a major cellular target in a variety of severe hepatobiliary diseases are currently being investigated, many questions remain unanswered, particularly regarding cholangiocellular functions, both in normal and abnormal conditions. As current experimental models become more refined, scientists with interests as diverse as cell biology and physiology, morphology, pharmacology, immunology, genetics, and oncology can be expected to further clarify the pathobiology of biliary epithelia.

UR - http://www.scopus.com/inward/record.url?scp=0031031016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031031016&partnerID=8YFLogxK

M3 - Article

C2 - 8978368

AN - SCOPUS:0031031016

VL - 112

SP - 269

EP - 279

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 1

ER -