The p120 catenin family: Complex roles in adhesion, signaling and cancer

Panos Z. Anastasiadis, Albert B. Reynolds

Research output: Contribution to journalComment/debate

364 Scopus citations

Abstract

p120 catenin (p120) is the prototypic member of a growing subfamily of Armadillo-domain proteins found at cell-cell junctions and in nuclei. In contrast to the functions of the classical catenins (α-catenin, β-catenin, and γ-catenin/plakoglobin), which have been studied extensively, the first clues to p120's biological function have only recently emerged, and its role remains controversial. Nonetheless, it is now clear that p120 affects cell-cell adhesion through its interaction with the highly conserved juxtamembrane domain of classical cadherins, and is likely to have additional roles in the nucleus. Here, we summarize the data on the potential involvement of p120 both in promotion of and in prevension of adhesion, and propose models that attempt to reconcile some of the disparities in the literature. We also discuss the structural relationships and functions of several known p120 family members, as well as the potential roles of p120 in signaling and cancer.

Original languageEnglish (US)
Pages (from-to)1319-1334
Number of pages16
JournalJournal of cell science
Volume113
Issue number8
StatePublished - May 16 2000

Keywords

  • ARVCF
  • Armadillo/β-catenin
  • Cadherin
  • Cell adhesion
  • Clustering
  • Kaiso
  • Plakophilin
  • Presenilin
  • RhoA
  • p0071
  • p120(ctn)
  • δ-catenin/NPRAP/neurojungin

ASJC Scopus subject areas

  • Cell Biology

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