TY - JOUR
T1 - The Oxfordshire Community Stroke Project Classification
T2 - Correlation with imaging, associated complications, and prediction of outcome in acute ischemic stroke
AU - Pittock, Sean J.
AU - Meldrum, Dara
AU - Hardiman, Orla
AU - Thornton, John
AU - Brennan, Paul
AU - Moroney, Joan T.
N1 - Funding Information:
Supported in part by a grant from Schering AG, Ireland (S. J. P.).
PY - 2003
Y1 - 2003
N2 - This preliminary study investigates the risk factor profile, post stroke complications, and outcome for four OCSP (Oxfordshire Community Stroke Project Classification) subtypes. One hundred seventeen consecutive ischemic stroke patients were clinically classified into I of 4 subtypes: total anterior (TACI), partial anterior (PACI), lacunar (LACI), and posterior (POCI) circulation infarcts. Study evaluations were performed at admission, 2 weeks, and 6 months. There was a good correlation between clinical classification and radiological diagnosis if a negative CT head was considered consistent with a lacunar infarction. No significant difference in risk factor profile was observed between subtypes. The TACI group had significantly higher mortality (P < .001), morbidity (P < .001, as per disability scales), length of hospital stay (P < .001), and complications (respiratory tract infection and seizures [P < .01]) as compared to the other three groups which were all similar at the different time points. The only significant difference found was the higher rate of stroke recurrence within the first 6 months in the POCI group (P < .001). The OCSP classification identifies two major groups (TACI and other 3 groups combined) who behave differently with respect to post stroke outcome. Further study with larger numbers of patients and thus greater power will be required to allow better discrimination of OCSP subtypes in respect of risk factors, complications, and outcomes if the OCSP is to be used to stratify patients in clinical trials.
AB - This preliminary study investigates the risk factor profile, post stroke complications, and outcome for four OCSP (Oxfordshire Community Stroke Project Classification) subtypes. One hundred seventeen consecutive ischemic stroke patients were clinically classified into I of 4 subtypes: total anterior (TACI), partial anterior (PACI), lacunar (LACI), and posterior (POCI) circulation infarcts. Study evaluations were performed at admission, 2 weeks, and 6 months. There was a good correlation between clinical classification and radiological diagnosis if a negative CT head was considered consistent with a lacunar infarction. No significant difference in risk factor profile was observed between subtypes. The TACI group had significantly higher mortality (P < .001), morbidity (P < .001, as per disability scales), length of hospital stay (P < .001), and complications (respiratory tract infection and seizures [P < .01]) as compared to the other three groups which were all similar at the different time points. The only significant difference found was the higher rate of stroke recurrence within the first 6 months in the POCI group (P < .001). The OCSP classification identifies two major groups (TACI and other 3 groups combined) who behave differently with respect to post stroke outcome. Further study with larger numbers of patients and thus greater power will be required to allow better discrimination of OCSP subtypes in respect of risk factors, complications, and outcomes if the OCSP is to be used to stratify patients in clinical trials.
KW - Acute ischemic stroke
KW - Cerebral infarct
KW - OCSP
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U2 - 10.1053/jscd.2003.7
DO - 10.1053/jscd.2003.7
M3 - Article
C2 - 17903897
AN - SCOPUS:0037221266
SN - 1052-3057
VL - 12
SP - 1
EP - 7
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
IS - 1
ER -