The Oslo definitions for coeliac disease and related terms

Jonas F. Ludvigsson, Daniel A. Leffler, Julio C. Bai, Federico Biagi, Alessio Fasano, Peter H R Green, Marios Hadjivassiliou, Katri Kaukinen, Ciaran P. Kelly, Jonathan N. Leonard, Knut Erik Aslaksen Lundin, Joseph A Murray, David S. Sanders, Marjorie M. Walker, Fabiana Zingone, Carolina Ciacci

Research output: Contribution to journalArticle

758 Citations (Scopus)

Abstract

Objective: The literature suggests a lack of consensus on the use of terms related to coeliac disease (CD) and gluten. Design: A multidisciplinary task force of 16 physicians from seven countries used the electronic database PubMed to review the literature for CD-related terms up to January 2011. Teams of physicians then suggested a definition for each term, followed by feedback of these definitions through a web survey on definitions, discussions during a meeting in Oslo and phone conferences. In addition to 'CD', the following descriptors of CD were evaluated (in alphabetical order): asymptomatic, atypical, classical, latent, non-classical, overt, paediatric classical, potential, refractory, silent, subclinical, symptomatic, typical, CD serology, CD autoimmunity, genetically at risk of CD, dermatitis herpetiformis, gluten, gluten ataxia, gluten intolerance, gluten sensitivity and gliadin-specific antibodies. Results: CD was defined as 'a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals'. Classical CD was defined as 'CD presenting with signs and symptoms of malabsorption. Diarrhoea, steatorrhoea, weight loss or growth failure is required.' 'Gluten-related disorders' is the suggested umbrella term for all diseases triggered by gluten and the term gluten intolerance should not to be used. Other definitions are presented in the paper. Conclusion: This paper presents the Oslo definitions for CD-related terms.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalGut
Volume62
Issue number1
DOIs
StatePublished - Jan 2013

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Celiac Disease
Glutens
Dermatitis Herpetiformis
Steatorrhea
Physicians
Gliadin
Advisory Committees
Serology
Ataxia
Autoimmunity
PubMed
Signs and Symptoms
Weight Loss
Diarrhea
Databases
Pediatrics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ludvigsson, J. F., Leffler, D. A., Bai, J. C., Biagi, F., Fasano, A., Green, P. H. R., ... Ciacci, C. (2013). The Oslo definitions for coeliac disease and related terms. Gut, 62(1), 43-52. https://doi.org/10.1136/gutjnl-2011-301346

The Oslo definitions for coeliac disease and related terms. / Ludvigsson, Jonas F.; Leffler, Daniel A.; Bai, Julio C.; Biagi, Federico; Fasano, Alessio; Green, Peter H R; Hadjivassiliou, Marios; Kaukinen, Katri; Kelly, Ciaran P.; Leonard, Jonathan N.; Lundin, Knut Erik Aslaksen; Murray, Joseph A; Sanders, David S.; Walker, Marjorie M.; Zingone, Fabiana; Ciacci, Carolina.

In: Gut, Vol. 62, No. 1, 01.2013, p. 43-52.

Research output: Contribution to journalArticle

Ludvigsson, JF, Leffler, DA, Bai, JC, Biagi, F, Fasano, A, Green, PHR, Hadjivassiliou, M, Kaukinen, K, Kelly, CP, Leonard, JN, Lundin, KEA, Murray, JA, Sanders, DS, Walker, MM, Zingone, F & Ciacci, C 2013, 'The Oslo definitions for coeliac disease and related terms', Gut, vol. 62, no. 1, pp. 43-52. https://doi.org/10.1136/gutjnl-2011-301346
Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PHR et al. The Oslo definitions for coeliac disease and related terms. Gut. 2013 Jan;62(1):43-52. https://doi.org/10.1136/gutjnl-2011-301346
Ludvigsson, Jonas F. ; Leffler, Daniel A. ; Bai, Julio C. ; Biagi, Federico ; Fasano, Alessio ; Green, Peter H R ; Hadjivassiliou, Marios ; Kaukinen, Katri ; Kelly, Ciaran P. ; Leonard, Jonathan N. ; Lundin, Knut Erik Aslaksen ; Murray, Joseph A ; Sanders, David S. ; Walker, Marjorie M. ; Zingone, Fabiana ; Ciacci, Carolina. / The Oslo definitions for coeliac disease and related terms. In: Gut. 2013 ; Vol. 62, No. 1. pp. 43-52.
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