The origin and behavior of two isodicentric bisatellited chromosomes

D. L. Van Dyke, L. Weiss, M. Logan, G. S. Pai

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Karyotyping revealed three cell lines in a boy with mental retardation and few other abnormalities. Thirty cells exhibited a normal karyotype, and 54 had an extra acrocentric chromosome of E group size with satellites on the long and short arms. The remaining 20 cells each had, in addition to the first marker (M1), a second tiny bisatellited chromosome (M2). C-banding demonstrated that both markers were dicentric. G-,C-, and Q-banding and satellite association data were consistent with the markers having originated from chromosome 15 material. We propose that M1 was formed from a meiotic breakage and a chromatid fusion in the proximal long arms of an acrocentric pair. This would have produced a symmetrical isodicentric chromosome, plus one or two acentric fragments. M2 then could have resulted from a dicentric bridge-break-synthesis-reunion phenomenon. This model of abnormal meiotic exchange can be generalized to encompass the formation of other dicentric isochromosome cases of isochromosome X.

Original languageEnglish (US)
Pages (from-to)294-300
Number of pages7
JournalAmerican Journal of Human Genetics
Volume29
Issue number3
StatePublished - 1977
Externally publishedYes

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Isochromosomes
Chromosomes, Human, 16-18
Chromosomes
Reunion
Chromosomes, Human, Pair 15
Karyotyping
Chromatids
Karyotype
Intellectual Disability
Cell Line

ASJC Scopus subject areas

  • Genetics

Cite this

Van Dyke, D. L., Weiss, L., Logan, M., & Pai, G. S. (1977). The origin and behavior of two isodicentric bisatellited chromosomes. American Journal of Human Genetics, 29(3), 294-300.

The origin and behavior of two isodicentric bisatellited chromosomes. / Van Dyke, D. L.; Weiss, L.; Logan, M.; Pai, G. S.

In: American Journal of Human Genetics, Vol. 29, No. 3, 1977, p. 294-300.

Research output: Contribution to journalArticle

Van Dyke, DL, Weiss, L, Logan, M & Pai, GS 1977, 'The origin and behavior of two isodicentric bisatellited chromosomes', American Journal of Human Genetics, vol. 29, no. 3, pp. 294-300.
Van Dyke, D. L. ; Weiss, L. ; Logan, M. ; Pai, G. S. / The origin and behavior of two isodicentric bisatellited chromosomes. In: American Journal of Human Genetics. 1977 ; Vol. 29, No. 3. pp. 294-300.
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