The optimal management of the axillae of patients with microinvasive breast cancer in the sentinel lymph node era

Richard J. Gray, Bryan Mulheron, Barbara A Pockaj, Amy C Degnim, Stephen L. Smith

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: For patients with microinvasive breast cancer, the value of intraoperative analysis of sentinel lymph nodes (SLNs) and complete axillary lymph node dissection (CALND) is not well known. Methods: All patients staged T1mic from 2001 to 2005 were analyzed. Results: Among all 81 patients, 4 (5%) had SLN metastases detected with hematoxylin and eosin staining and 2 (2%) had metastases identified by immunohistochemistry staining only. Seventy-seven patients (95%) underwent SLN biopsy; 3 (4%) had hematoxylin and eosin SLN metastases and 2 (3%) had immunohistochemistry-detected metastases. One SLN metastasis was identified on frozen section analysis. No patient with a SLN metastasis had additional metastases on CALND. The patient charges for frozen section analyses were $39,578 for 77 patients. This prevented 1 reoperative CALND at a charge of $20,274. Conclusions: Frozen section analysis should be used only in select patients with microinvasive breast cancer and CALND is of limited value for these patients.

Original languageEnglish (US)
Pages (from-to)845-849
Number of pages5
JournalAmerican Journal of Surgery
Volume194
Issue number6
DOIs
StatePublished - Dec 2007

Fingerprint

Axilla
Breast Neoplasms
Neoplasm Metastasis
Lymph Node Excision
Frozen Sections
Hematoxylin
Eosine Yellowish-(YS)
Immunohistochemistry
Staining and Labeling
Sentinel Lymph Node
Sentinel Lymph Node Biopsy

Keywords

  • Breast cancer
  • Ductal carcinoma-in-situ with microinvasion
  • Frozen section analysis
  • Microinvasion
  • Sentinel node

ASJC Scopus subject areas

  • Surgery

Cite this

The optimal management of the axillae of patients with microinvasive breast cancer in the sentinel lymph node era. / Gray, Richard J.; Mulheron, Bryan; Pockaj, Barbara A; Degnim, Amy C; Smith, Stephen L.

In: American Journal of Surgery, Vol. 194, No. 6, 12.2007, p. 845-849.

Research output: Contribution to journalArticle

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AU - Degnim, Amy C

AU - Smith, Stephen L.

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