The oesophagus and cough: Laryngo-pharyngeal reflux, microaspiration and vagal reflexes

Jaclyn A. Smith, Lesley A. Houghton

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Gastro-oesophageal reflux disease is generally considered to be one of the commonest causes of chronic cough, however randomised controlled trials of proton pump inhibitors have often failed to support this notion. This article reviews the most recent studies investigating the mechanisms thought to link reflux and cough, namely laryngo-pharyngeal reflux, micro-aspiration and neuronal cross-organ sensitisation. How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed.

Original languageEnglish (US)
Article number12
JournalCough
Volume9
Issue number1
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pulmonary and Respiratory Medicine

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