The number and sizes of reconstructed peripheral autonomic, sensory and motor neurons in a case of dysautonomia

Peter J Dyck, Y. Kawamura, Phillip Anson Low, M. Shimono, J. S. Solovy

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Motor, spinal ganglion, intermediolateral and sympathetic trunk neurons were reconstructed by morphometric sampling of their cell bodies at L5 and T7 segments and at various levels of spinal roots and peripheral nerves in a 31-year-old patient with dysautonomia and compared to reference cases. The patient had strikingly fewer intermediate motoneuron column neurons and intermediate ventral root axons (probably gamma motoneurons), spinal ganglion neurons, preganglionic autonomic neurons and sympathetic trunk neurons than did controls (~ 10-30% of reference values). The striking agreement between selective absence of intermediate-diameter cytons (C 1) and of intermediate diameter myelinated fibers (A 1), which are thought to be gamma efferent, of L5 motoneuron columns provides further confirmation to our previous suggestion that the C 1 peak of motoneuron columns are somas of gamma efferent neurons. The number and size of alpha motoneuron cell bodies and their proximal axons were like those of controls but their distal axons were probably atrophic. This finding probably explains the small reduction in maximum conduction velocity of motor nerve fibers found in this disorder. The brunt of the pathologic process in this disorder has been borne by intermediate and small neurons preferentially.

Original languageEnglish (US)
Pages (from-to)741-755
Number of pages15
JournalJournal of Neuropathology and Experimental Neurology
Volume37
Issue number6
StatePublished - 1978

Fingerprint

Primary Dysautonomias
Motor Neurons
Sensory Receptor Cells
Neurons
Axons
Spinal Nerve Roots
Spinal Ganglia
Efferent Neurons
Spinal Nerves
Carisoprodol
Pathologic Processes
Peripheral Nerves
Nerve Fibers
Reference Values

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

The number and sizes of reconstructed peripheral autonomic, sensory and motor neurons in a case of dysautonomia. / Dyck, Peter J; Kawamura, Y.; Low, Phillip Anson; Shimono, M.; Solovy, J. S.

In: Journal of Neuropathology and Experimental Neurology, Vol. 37, No. 6, 1978, p. 741-755.

Research output: Contribution to journalArticle

@article{1d2466d31b01413e846e289c022697e1,
title = "The number and sizes of reconstructed peripheral autonomic, sensory and motor neurons in a case of dysautonomia",
abstract = "Motor, spinal ganglion, intermediolateral and sympathetic trunk neurons were reconstructed by morphometric sampling of their cell bodies at L5 and T7 segments and at various levels of spinal roots and peripheral nerves in a 31-year-old patient with dysautonomia and compared to reference cases. The patient had strikingly fewer intermediate motoneuron column neurons and intermediate ventral root axons (probably gamma motoneurons), spinal ganglion neurons, preganglionic autonomic neurons and sympathetic trunk neurons than did controls (~ 10-30{\%} of reference values). The striking agreement between selective absence of intermediate-diameter cytons (C 1) and of intermediate diameter myelinated fibers (A 1), which are thought to be gamma efferent, of L5 motoneuron columns provides further confirmation to our previous suggestion that the C 1 peak of motoneuron columns are somas of gamma efferent neurons. The number and size of alpha motoneuron cell bodies and their proximal axons were like those of controls but their distal axons were probably atrophic. This finding probably explains the small reduction in maximum conduction velocity of motor nerve fibers found in this disorder. The brunt of the pathologic process in this disorder has been borne by intermediate and small neurons preferentially.",
author = "Dyck, {Peter J} and Y. Kawamura and Low, {Phillip Anson} and M. Shimono and Solovy, {J. S.}",
year = "1978",
language = "English (US)",
volume = "37",
pages = "741--755",
journal = "American Journal of Psychotherapy",
issn = "0002-9564",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - The number and sizes of reconstructed peripheral autonomic, sensory and motor neurons in a case of dysautonomia

AU - Dyck, Peter J

AU - Kawamura, Y.

AU - Low, Phillip Anson

AU - Shimono, M.

AU - Solovy, J. S.

PY - 1978

Y1 - 1978

N2 - Motor, spinal ganglion, intermediolateral and sympathetic trunk neurons were reconstructed by morphometric sampling of their cell bodies at L5 and T7 segments and at various levels of spinal roots and peripheral nerves in a 31-year-old patient with dysautonomia and compared to reference cases. The patient had strikingly fewer intermediate motoneuron column neurons and intermediate ventral root axons (probably gamma motoneurons), spinal ganglion neurons, preganglionic autonomic neurons and sympathetic trunk neurons than did controls (~ 10-30% of reference values). The striking agreement between selective absence of intermediate-diameter cytons (C 1) and of intermediate diameter myelinated fibers (A 1), which are thought to be gamma efferent, of L5 motoneuron columns provides further confirmation to our previous suggestion that the C 1 peak of motoneuron columns are somas of gamma efferent neurons. The number and size of alpha motoneuron cell bodies and their proximal axons were like those of controls but their distal axons were probably atrophic. This finding probably explains the small reduction in maximum conduction velocity of motor nerve fibers found in this disorder. The brunt of the pathologic process in this disorder has been borne by intermediate and small neurons preferentially.

AB - Motor, spinal ganglion, intermediolateral and sympathetic trunk neurons were reconstructed by morphometric sampling of their cell bodies at L5 and T7 segments and at various levels of spinal roots and peripheral nerves in a 31-year-old patient with dysautonomia and compared to reference cases. The patient had strikingly fewer intermediate motoneuron column neurons and intermediate ventral root axons (probably gamma motoneurons), spinal ganglion neurons, preganglionic autonomic neurons and sympathetic trunk neurons than did controls (~ 10-30% of reference values). The striking agreement between selective absence of intermediate-diameter cytons (C 1) and of intermediate diameter myelinated fibers (A 1), which are thought to be gamma efferent, of L5 motoneuron columns provides further confirmation to our previous suggestion that the C 1 peak of motoneuron columns are somas of gamma efferent neurons. The number and size of alpha motoneuron cell bodies and their proximal axons were like those of controls but their distal axons were probably atrophic. This finding probably explains the small reduction in maximum conduction velocity of motor nerve fibers found in this disorder. The brunt of the pathologic process in this disorder has been borne by intermediate and small neurons preferentially.

UR - http://www.scopus.com/inward/record.url?scp=0018216601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018216601&partnerID=8YFLogxK

M3 - Article

C2 - 739275

AN - SCOPUS:0018216601

VL - 37

SP - 741

EP - 755

JO - American Journal of Psychotherapy

JF - American Journal of Psychotherapy

SN - 0002-9564

IS - 6

ER -