The nucleus accumbens as a potential target for central poststroke pain

Grant W. Mallory, Osama Abulseoud, Sun Chul Hwang, Deborah A. Gorman, Squire Matthew Stead, Bryan Klassen, Paola Sandroni, James Watson, Kendall H Lee

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Although deep brain stimulation (DBS) has been found to be efficacious for some chronic pain syndromes, its usefulness in patients with central poststroke pain (CPSP) has been disappointing. The most common DBS targets for pain are the periventricular gray region (PVG) and the ventralis caudalis of the thalamus. Despite the limited success of DBS for CPSP, few alternative targets have been explored. The nucleus accumbens (NAC), a limbic structure within the ventral striatum that is involved in reward and pain processing, has emerged as an effective target for psychiatric disease. There is also evidence that it may be an effective target for pain. We describe a 72-year-old woman with a large right hemisphere infarct who subsequently experienced refractory left hemibody pain. She underwent placement of 3 electrodes in the right PVG, ventralis caudalis of the thalamus, and NAC. Individual stimulation of the NAC and PVG provided substantial improvement in pain rating. The patient underwent implantation of permanent electrodes in both targets, and combined stimulation has provided sustained pain relief at nearly 1 year after the procedure. These results suggest that the NAC may be an effective DBS target for CPSP.

Original languageEnglish (US)
Pages (from-to)1025-1031
Number of pages7
JournalMayo Clinic Proceedings
Volume87
Issue number10
DOIs
StatePublished - Oct 2012

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Nucleus Accumbens
Pain
Deep Brain Stimulation
Thalamus
Electrodes
Reward
Chronic Pain
Psychiatry

ASJC Scopus subject areas

  • Medicine(all)

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The nucleus accumbens as a potential target for central poststroke pain. / Mallory, Grant W.; Abulseoud, Osama; Hwang, Sun Chul; Gorman, Deborah A.; Stead, Squire Matthew; Klassen, Bryan; Sandroni, Paola; Watson, James; Lee, Kendall H.

In: Mayo Clinic Proceedings, Vol. 87, No. 10, 10.2012, p. 1025-1031.

Research output: Contribution to journalArticle

Mallory, Grant W. ; Abulseoud, Osama ; Hwang, Sun Chul ; Gorman, Deborah A. ; Stead, Squire Matthew ; Klassen, Bryan ; Sandroni, Paola ; Watson, James ; Lee, Kendall H. / The nucleus accumbens as a potential target for central poststroke pain. In: Mayo Clinic Proceedings. 2012 ; Vol. 87, No. 10. pp. 1025-1031.
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