Abstract
Neurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin-related kinase receptor subtype B (TrkB). A novel flavonoid, 7,8-dihydroxyflavone (7,8-DHF), selectively activates TrkB receptors. Using TrkBF616A mice that are susceptible to specific inhibition of TrkB activity by 1NMPP1, we show that neuromuscular transmission is enhanced by 7,8-DHF (∼32%) via activation of TrkB in diaphragm muscle. The small molecule 7,8-DHF may constitute a novel therapy to improve neuromuscular function.
Original language | English (US) |
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Pages (from-to) | 274-276 |
Number of pages | 3 |
Journal | Muscle and Nerve |
Volume | 45 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2012 |
Keywords
- Flavones
- Muscle fatigue
- Neuromuscular transmission failure
- Neurotrophins
- Synaptic efficacy
ASJC Scopus subject areas
- Physiology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)