The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission

Carlos Bernardo Mantilla, Leonid G. Ermilov

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Neurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin-related kinase receptor subtype B (TrkB). A novel flavonoid, 7,8-dihydroxyflavone (7,8-DHF), selectively activates TrkB receptors. Using TrkBF616A mice that are susceptible to specific inhibition of TrkB activity by 1NMPP1, we show that neuromuscular transmission is enhanced by 7,8-DHF (∼32%) via activation of TrkB in diaphragm muscle. The small molecule 7,8-DHF may constitute a novel therapy to improve neuromuscular function.

Original languageEnglish (US)
Pages (from-to)274-276
Number of pages3
JournalMuscle and Nerve
Volume45
Issue number2
DOIs
StatePublished - Feb 2012

Fingerprint

Neuromuscular Junction
Nerve Growth Factors
Diaphragm
Flavonoids
Cholinergic Agents
Muscles
tropomyosin kinase
6,7-dihydroxyflavone
Therapeutics

Keywords

  • Flavones
  • Muscle fatigue
  • Neuromuscular transmission failure
  • Neurotrophins
  • Synaptic efficacy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

Cite this

The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission. / Mantilla, Carlos Bernardo; Ermilov, Leonid G.

In: Muscle and Nerve, Vol. 45, No. 2, 02.2012, p. 274-276.

Research output: Contribution to journalArticle

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