The natural history of unruptured intracranial arteriovenous malformations

Robert D Jr. Brown, D. O. Wiebers, G. Forbes, W. M. O'Fallon, D. G. Piepgras, W. R. Marsh, R. J. Maciunas

Research output: Contribution to journalArticle

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Abstract

The authors conducted a long-term follow-up study of 168 patients to define the natural history of clinically unruptured intracranial arteriovenous malformations (AVM's). Charts of patients seen at the Mayo Clinic between 1974 and 1985 were reviewed. Follow-up information was obtained on 166 patients until death, surgery, or other intervention, or for at least 4 years after diagnosis (mean follow-up time 8.2 years). All available cerebral arteriograms and computerized tomography scans of the head were reviewed. Intracranial hemorrhage occurred in 31 patients (18%), due to AVM rupture in 29 and secondary to AVM or aneurysm rupture in two. The mean risk of hemorrhage was 2.2% per year, and the observed annual rates of hemorrhage increased over time. The risk of death from rupture was 29%, and 23% of survivors has significant long-term morbidity.The size of the AVM and the presence of treated or untreated hypertension were of no value in predicting rupture.

Original languageEnglish (US)
Pages (from-to)352-357
Number of pages6
JournalJournal of Neurosurgery
Volume68
Issue number3
StatePublished - 1988

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Intracranial Arteriovenous Malformations
Natural History
Rupture
Arteriovenous Malformations
Hemorrhage
Intracranial Hemorrhages
Arteriovenous Fistula
Survivors
Head
Tomography
Hypertension
Morbidity

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Brown, R. D. J., Wiebers, D. O., Forbes, G., O'Fallon, W. M., Piepgras, D. G., Marsh, W. R., & Maciunas, R. J. (1988). The natural history of unruptured intracranial arteriovenous malformations. Journal of Neurosurgery, 68(3), 352-357.

The natural history of unruptured intracranial arteriovenous malformations. / Brown, Robert D Jr.; Wiebers, D. O.; Forbes, G.; O'Fallon, W. M.; Piepgras, D. G.; Marsh, W. R.; Maciunas, R. J.

In: Journal of Neurosurgery, Vol. 68, No. 3, 1988, p. 352-357.

Research output: Contribution to journalArticle

Brown, RDJ, Wiebers, DO, Forbes, G, O'Fallon, WM, Piepgras, DG, Marsh, WR & Maciunas, RJ 1988, 'The natural history of unruptured intracranial arteriovenous malformations', Journal of Neurosurgery, vol. 68, no. 3, pp. 352-357.
Brown RDJ, Wiebers DO, Forbes G, O'Fallon WM, Piepgras DG, Marsh WR et al. The natural history of unruptured intracranial arteriovenous malformations. Journal of Neurosurgery. 1988;68(3):352-357.
Brown, Robert D Jr. ; Wiebers, D. O. ; Forbes, G. ; O'Fallon, W. M. ; Piepgras, D. G. ; Marsh, W. R. ; Maciunas, R. J. / The natural history of unruptured intracranial arteriovenous malformations. In: Journal of Neurosurgery. 1988 ; Vol. 68, No. 3. pp. 352-357.
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