The natural history of peripheral neuropathy in primary systemic amyloidosis

J. J. Kelly, R. A. Kyle, P. C. O'Brien, Peter J Dyck

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

The records of 31 patients with primary systemic amyloidosis and peripheral neuropathy seen during a 17-year period were analyzed to define the natural history of the neuropathy. Patients tended to be older men with a painful, distal, symmetrical sensorimotor neuropathy and prominent autonomic features. Loss of pain and temperature sensation was frequently more striking than loss of mechanoreception. Renal, cardiac, hematological, and gastrointestinal dysfunction often overshadowed the neuropathy. Clinical, neurophysiological, and histopathological studies pointed to axonal degeneration with predominant but not exclusive involvement of small myelinated and unmyelinated fibers. The neuropathy was progressive in all patients with or without treatment, but death was typically due to supervening medical complications.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalAnnals of Neurology
Volume6
Issue number1
StatePublished - 1979

Fingerprint

Peripheral Nervous System Diseases
Natural History
Kidney
Pain
Temperature
Primary amyloidosis
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The natural history of peripheral neuropathy in primary systemic amyloidosis. / Kelly, J. J.; Kyle, R. A.; O'Brien, P. C.; Dyck, Peter J.

In: Annals of Neurology, Vol. 6, No. 1, 1979, p. 1-7.

Research output: Contribution to journalArticle

Kelly, J. J. ; Kyle, R. A. ; O'Brien, P. C. ; Dyck, Peter J. / The natural history of peripheral neuropathy in primary systemic amyloidosis. In: Annals of Neurology. 1979 ; Vol. 6, No. 1. pp. 1-7.
@article{6c3c402c02c4426eb52c8829eaac4878,
title = "The natural history of peripheral neuropathy in primary systemic amyloidosis",
abstract = "The records of 31 patients with primary systemic amyloidosis and peripheral neuropathy seen during a 17-year period were analyzed to define the natural history of the neuropathy. Patients tended to be older men with a painful, distal, symmetrical sensorimotor neuropathy and prominent autonomic features. Loss of pain and temperature sensation was frequently more striking than loss of mechanoreception. Renal, cardiac, hematological, and gastrointestinal dysfunction often overshadowed the neuropathy. Clinical, neurophysiological, and histopathological studies pointed to axonal degeneration with predominant but not exclusive involvement of small myelinated and unmyelinated fibers. The neuropathy was progressive in all patients with or without treatment, but death was typically due to supervening medical complications.",
author = "Kelly, {J. J.} and Kyle, {R. A.} and O'Brien, {P. C.} and Dyck, {Peter J}",
year = "1979",
language = "English (US)",
volume = "6",
pages = "1--7",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - The natural history of peripheral neuropathy in primary systemic amyloidosis

AU - Kelly, J. J.

AU - Kyle, R. A.

AU - O'Brien, P. C.

AU - Dyck, Peter J

PY - 1979

Y1 - 1979

N2 - The records of 31 patients with primary systemic amyloidosis and peripheral neuropathy seen during a 17-year period were analyzed to define the natural history of the neuropathy. Patients tended to be older men with a painful, distal, symmetrical sensorimotor neuropathy and prominent autonomic features. Loss of pain and temperature sensation was frequently more striking than loss of mechanoreception. Renal, cardiac, hematological, and gastrointestinal dysfunction often overshadowed the neuropathy. Clinical, neurophysiological, and histopathological studies pointed to axonal degeneration with predominant but not exclusive involvement of small myelinated and unmyelinated fibers. The neuropathy was progressive in all patients with or without treatment, but death was typically due to supervening medical complications.

AB - The records of 31 patients with primary systemic amyloidosis and peripheral neuropathy seen during a 17-year period were analyzed to define the natural history of the neuropathy. Patients tended to be older men with a painful, distal, symmetrical sensorimotor neuropathy and prominent autonomic features. Loss of pain and temperature sensation was frequently more striking than loss of mechanoreception. Renal, cardiac, hematological, and gastrointestinal dysfunction often overshadowed the neuropathy. Clinical, neurophysiological, and histopathological studies pointed to axonal degeneration with predominant but not exclusive involvement of small myelinated and unmyelinated fibers. The neuropathy was progressive in all patients with or without treatment, but death was typically due to supervening medical complications.

UR - http://www.scopus.com/inward/record.url?scp=0018392298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018392298&partnerID=8YFLogxK

M3 - Article

VL - 6

SP - 1

EP - 7

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 1

ER -