TY - JOUR
T1 - The natural history of multiple sclerosis
T2 - Implications for trial design
AU - Wingerchuk, Dean M.
AU - Weinshenker, Brian G.
PY - 1999
Y1 - 1999
N2 - The understanding of the natural history of multiple sclerosis has many implications for the design and interpretation of randomized controlled trials. Selection criteria, patient stratification, outcome measurements, and definitions of treatment failure can influence randomized controlled trial results and limit comparisons among trials. The focus of future studies should shift from short-term determinations of efficacy to definitive evaluations of long-term effectiveness. This will require novel investigative strategies such as the use of historic controls derived from natural history studies.
AB - The understanding of the natural history of multiple sclerosis has many implications for the design and interpretation of randomized controlled trials. Selection criteria, patient stratification, outcome measurements, and definitions of treatment failure can influence randomized controlled trial results and limit comparisons among trials. The focus of future studies should shift from short-term determinations of efficacy to definitive evaluations of long-term effectiveness. This will require novel investigative strategies such as the use of historic controls derived from natural history studies.
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U2 - 10.1097/00019052-199906000-00013
DO - 10.1097/00019052-199906000-00013
M3 - Short survey
C2 - 10499179
AN - SCOPUS:0032773375
SN - 1350-7540
VL - 12
SP - 345
EP - 349
JO - Current opinion in neurology
JF - Current opinion in neurology
IS - 3
ER -