The natural history of multiple sclerosis

Brian G Weinshenker, G. C. Ebers

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Studies which have attempted to define the outcome ot multiple sclerosis (MS) have methodologic difficulties arising from patient referral biases and the length of follow-up required, which make prospective studies of an inception cohort unrealistic. Means to improve the validity of retrospective natural history studies are suggested. Results of existing series are summarized and compared. Survival is only rarely shortened by MS, but disability to the point of requiring aids for ambulation occurs in 30-70% of patients by 15 years from onset of symptoms. Disagreement as to the percentage of patients who are ultimately bedridden by MS likely arises in large part due to differences in patient ascertainment and follow-up. The need to develop early clinical markers for the patient at high risk for rapid development of major disability is stressed.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalCanadian Journal of Neurological Sciences
Volume14
Issue number3
StatePublished - 1987
Externally publishedYes

Fingerprint

Multiple Sclerosis
Natural History
Walking
Referral and Consultation
Biomarkers
Prospective Studies
Survival

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

The natural history of multiple sclerosis. / Weinshenker, Brian G; Ebers, G. C.

In: Canadian Journal of Neurological Sciences, Vol. 14, No. 3, 1987, p. 255-261.

Research output: Contribution to journalArticle

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