The Natural History of Asymptomatic Carotid Artery Occlusive Lesions

Irene Meissner, David O. Wiebers, Jack P. Whisnant, W. Michael O’fallon

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The purpose of this retrospective study was to determine the long-term prognosis of patients with asymptomatic pressure-significant (hemodynamically significant) internal carotid system lesions. Of 640 neurologically asymptomatic patients, 292 had pressure-significant internal carotid artery occlusive lesions as determined by ocular pneumoplethysmography, while 348 had a carotid bruit only without a pressure-significant lesion. The annual stroke rate for the first three years on a Kaplan-Meier life-table basis was 3.4% and 1.5% in the abnormal and normal ocular pneumoplethysmography groups, respectively, as compared with a rate of 0.5% in a normal age- and sex-matched population. The annual total event rate (transient ischemic attack and stroke) was 5.2% in the abnormal vs 2.3% in the normal group, with 56% of all events ipsilateral to the ocular pneumoplethysmography abnormality. These results indicate that patients with asymptomatic pressure-significant carotid system occlusive lesions are at greater risk for stroke than a normal ocular pneumoplethysmography group (twofold) and a general population (sevenfold).

Original languageEnglish (US)
Pages (from-to)2704-2707
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume258
Issue number19
DOIs
StatePublished - Nov 20 1987

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Natural History
Carotid Arteries
Pressure
Stroke
Eye Abnormalities
Life Tables
Transient Ischemic Attack
Internal Carotid Artery
Population
Retrospective Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The Natural History of Asymptomatic Carotid Artery Occlusive Lesions. / Meissner, Irene; Wiebers, David O.; Whisnant, Jack P.; O’fallon, W. Michael.

In: JAMA: The Journal of the American Medical Association, Vol. 258, No. 19, 20.11.1987, p. 2704-2707.

Research output: Contribution to journalArticle

Meissner, Irene ; Wiebers, David O. ; Whisnant, Jack P. ; O’fallon, W. Michael. / The Natural History of Asymptomatic Carotid Artery Occlusive Lesions. In: JAMA: The Journal of the American Medical Association. 1987 ; Vol. 258, No. 19. pp. 2704-2707.
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