The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

David S. Knopman, Samantha Budd Haeberlein, Maria C. Carrillo, James A. Hendrix, Geoff Kerchner, Richard Margolin, Paul Maruff, David S. Miller, Gary Tong, Maria B. Tome, Melissa E. Murray, Peter T. Nelson, Mary Sano, Niklas Mattsson, David L. Sultzer, Thomas J. Montine, Clifford R. Jack, Hartmuth Kolb, Ronald C. Petersen, Prashanthi VemuriMegan Zoschg Canniere, Julie A. Schneider, Susan M. Resnick, Gary Romano, Argonde Corien van Harten, David A. Wolk, Lisa J. Bain, Eric Siemers

Research output: Contribution to journalShort survey

36 Scopus citations

Abstract

The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the “A, T, N System” (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed.

Original languageEnglish (US)
Pages (from-to)563-575
Number of pages13
JournalAlzheimer's and Dementia
Volume14
Issue number4
DOIs
StatePublished - Apr 2018

Keywords

  • Alzheimer's disease
  • Amyloid
  • Biomarkers
  • Clinical trials
  • Neurodegeneration
  • Tau

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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    Knopman, D. S., Haeberlein, S. B., Carrillo, M. C., Hendrix, J. A., Kerchner, G., Margolin, R., Maruff, P., Miller, D. S., Tong, G., Tome, M. B., Murray, M. E., Nelson, P. T., Sano, M., Mattsson, N., Sultzer, D. L., Montine, T. J., Jack, C. R., Kolb, H., Petersen, R. C., ... Siemers, E. (2018). The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable. Alzheimer's and Dementia, 14(4), 563-575. https://doi.org/10.1016/j.jalz.2018.03.002