The movement disorders of adult opsoclonus

John N. Caviness, Peter A. Forsyth, Donald D. Layton, Thomas J. McPhee

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


We present three cases of the adult opsoclonus‐myoclonus syndrome in patients with systemic carcinoma. In addition to opsoclonus and myoclonus, other clinical components of the syndrome can include ataxia, tremor, gait and stance dysfunction, altered mental status, and head and face dyskinesias. The most common etiologies are idiopathic, paraneoplastic, and infectious encephalitis. Radiographic and pathological studies suggest brainstem stem dysfunctiion with associated cerebellar and/or cerebellar pathway dysfunction. In many cases, there is evidence for the involvement of immunologic and/or inflammatory processes in the pathogenesis of this syndrome. The timely recognition of this syndrome is important because of its implications for the underlying etiology and prognosis. The appearance of this syndrome should prompt the search for an occult malignancy.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalMovement Disorders
Issue number1
StatePublished - Jan 1995


  • Adult opsoclonus
  • Myoclonus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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