The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene

P. G. Olsson, C. Lohning, S. Horsley, L. Kearney, P. C. Harris, A. M. Frischauf

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The mouse homologue of the polycystic kidney disease 1 gene (PKD1) was mapped to chromosome 17 using somatic cell hybrids, B x D recombinant inbred strains, and FISH. The gene is located within a previously defined conserved synteny group that includes the mouse homologue of tuberous sclerosis 2 (TSC2) and is linked to the α globin pseudogene Hba-ps4. Although the human genome contains multiple copies of genes related to PKD1, there is no evidence for more than one copy in the mouse genome. Like their human counterparts, the mouse Tsc2 and Pkd1 genes are arranged in a tail-to-tail orientation with a distance of only 63 bp between the polyadenylation signals of the two genes.

Original languageEnglish (US)
Pages (from-to)233-235
Number of pages3
JournalGenomics
Volume34
Issue number2
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene'. Together they form a unique fingerprint.

Cite this