@article{b7f487091c8542619faab525a3e2852a,
title = "The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene",
abstract = "The mouse homologue of the polycystic kidney disease 1 gene (PKD1) was mapped to chromosome 17 using somatic cell hybrids, B x D recombinant inbred strains, and FISH. The gene is located within a previously defined conserved synteny group that includes the mouse homologue of tuberous sclerosis 2 (TSC2) and is linked to the α globin pseudogene Hba-ps4. Although the human genome contains multiple copies of genes related to PKD1, there is no evidence for more than one copy in the mouse genome. Like their human counterparts, the mouse Tsc2 and Pkd1 genes are arranged in a tail-to-tail orientation with a distance of only 63 bp between the polyadenylation signals of the two genes.",
author = "Olsson, {P. G.} and C. Lohning and S. Horsley and L. Kearney and Harris, {P. C.} and Frischauf, {A. M.}",
note = "Funding Information: We thank Dr. Cathy Price (LRF Centre at the Institute of Cancer Research, Chester Beatty Laboratories, London) for help with the CCD imaging. Mouse Pkd1 cDNA clones from the 3′ end were isolated using as probe the human cDNA clone pKG8 isolated by G. G. Germino (John Hopkins) while he was working in the laboratory of S. T. Reeders at Yale. We thank M. C. Schneider and S. T. Reeders for discussion. C. L. was the recipient of a postdoctoral fellowship of the Deutsche Forschungsgemeinschaft. This work was supported by the MRC, the ICRF, and Action Research.",
year = "1996",
doi = "10.1006/geno.1996.0273",
language = "English (US)",
volume = "34",
pages = "233--235",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "2",
}