The mouse 5-HT2B receptor: homologous subtype or species variant?

Doo Sup Choi, Sylvain Loric, Jean François Colas, Jacques Callebert, Philippe Rosay, Odile Kellermann, Jean Marie Launay, Luc Maroteaux

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The recently characterized 5-HT2B subfamily of serotonin receptors has now been reported from three different species: human, rat and mouse. Their genomic structures include 2 introns present at identical positions. Despite this similarity, their respective protein sequences show some diversities. In addition, the pharmacology of these receptors is distantly related, and their sites of expression vary amongst species. Thus, it appears difficult at present to unambiguously classify these receptors into the same subfamily, raising the possibility of the existence of other 5-HT2B-like receptors, yet to be discovered.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalBehavioural Brain Research
Volume73
Issue number1-2
DOIs
StatePublished - Dec 15 1995

Keywords

  • Drosophila
  • Human
  • Mouse
  • Rat
  • Serotonin receptor

ASJC Scopus subject areas

  • Behavioral Neuroscience

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