The Modulating Effects of Cardiac Resynchronization Therapy on Myocardial Metabolism in Heart Failure

Yi Zhou Xu, Chao Feng Chen, Bin Chen, Xiao Fei Gao, Wei Hua, Yong-Mei Cha, Petras P Dzeja

Research output: Contribution to journalReview article

2 Scopus citations


Heart failure (HF) is associated with changes in cardiac substrate utilization and energy metabolism, including a decline in high-energy phosphate content, mitochondrial dysfunction, and phosphotransfer enzyme deficiency. A shift toward glucose metabolism was noted in the end stage of HF in animals, although HF in humans may not be associated with a shift toward predominant glucose utilization. Deficiencies of micronutrients are well-established causes of cardiomyopathy. Correction of these deficits can improve heart function. The genes governing the energy metabolism were predominantly underexpressed in nonischemic cardiomyopathy and hypertrophic cardiomyopathy but were overexpressed in ischemic cardiomyopathy. Cardiac resynchronization therapy (CRT) has been proven to increase cardiac efficiency without increasing myocardial oxygen consumption. Altered myocardial metabolism is normalized by CRT to improve ventricular function.

Original languageEnglish (US)
Pages (from-to)1404-1409
Number of pages6
JournalPACE - Pacing and Clinical Electrophysiology
Issue number12
StatePublished - Dec 1 2016



  • cardiac resynchronization therapy
  • heart failure
  • metabolism
  • metabolomics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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