TY - JOUR
T1 - The mitotic checkpoint in cancer and aging
T2 - What have mice taught us?
AU - Baker, Darren J.
AU - Chen, Junjie
AU - Van Deursen, Jan M.A.
N1 - Funding Information:
We would like to thank Meelad Dawlaty for critical evaluation of the manuscript and helpful discussions. Supported by grants from the NIH (R01-CA96985 and R01-CA77262).
PY - 2005/12
Y1 - 2005/12
N2 - The spindle assembly checkpoint is a cellular surveillance mechanism that functions to ensure faithful chromosome segregation during mitosis. Failure of this checkpoint can result in aneuploidy, a state of having abnormal numbers of chromosomes. Most human cancers consist of aneuploid cells, but it is unclear if the aneuploidy is a cause or a consequence of tumorigenesis. Over recent years, mouse models for spindle assembly checkpoint failure have been generated to investigate the biological relevance of the different spindle assembly checkpoint genes and the pathologies associated with chromosome number instability. Most of these models exhibit susceptibility to carcinogenesis. Moreover, one model has led to the identification of the spindle checkpoint protein BubR1 as a regulator of the normal aging process.
AB - The spindle assembly checkpoint is a cellular surveillance mechanism that functions to ensure faithful chromosome segregation during mitosis. Failure of this checkpoint can result in aneuploidy, a state of having abnormal numbers of chromosomes. Most human cancers consist of aneuploid cells, but it is unclear if the aneuploidy is a cause or a consequence of tumorigenesis. Over recent years, mouse models for spindle assembly checkpoint failure have been generated to investigate the biological relevance of the different spindle assembly checkpoint genes and the pathologies associated with chromosome number instability. Most of these models exhibit susceptibility to carcinogenesis. Moreover, one model has led to the identification of the spindle checkpoint protein BubR1 as a regulator of the normal aging process.
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U2 - 10.1016/j.ceb.2005.09.011
DO - 10.1016/j.ceb.2005.09.011
M3 - Review article
C2 - 16226453
AN - SCOPUS:27544515607
SN - 0955-0674
VL - 17
SP - 583
EP - 589
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 6
ER -