The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism

Michelle Grace Acoba, Ebru S.Selen Alpergin, Renuse Santosh, Lucía Fernández-del-Río, Ya Wen Lu, Oleh Khalimonchuk, Catherine F. Clarke, Akhilesh Pandey, Michael J. Wolfgang, Steven M. Claypool

Research output: Contribution to journalArticlepeer-review

Abstract

Acoba et al. show that the amino acid transporter SFXN1 is a cargo of the TIM22 translocon that is important for maintaining complex III function and supports coenzyme Q, heme, and α-ketoglutarate metabolism.

Original languageEnglish (US)
Article number108869
JournalCell reports
Volume34
Issue number11
DOIs
StatePublished - Mar 16 2021

Keywords

  • amino acid
  • Complex III
  • heme
  • mitochondria
  • mitochondrial carrier
  • OXPHOS
  • serine
  • SFXN1
  • sideroflexin
  • TIM22 complex

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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