The minnesota center for twin and family research genome-wide association study

Michael B. Miller; Saonli Basu; Julie Cunningham; Eleazar Eskin; Steven M. Malone; William S. Oetting; Nicholas Schork; Jae Hoon Sul; William G. Iacono; Matt Mc Gue

doi:10.1017/thg.2012.62

The minnesota center for twin and family research genome-wide association study

Michael B. Miller, Saonli Basu, Julie Cunningham, Eleazar Eskin, Steven M. Malone, William S. Oetting, Nicholas Schork, Jae Hoon Sul, William G. Iacono, Matt Mc Gue

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

As part of the Genes, Environment and Development Initiative, the Minnesota Center for Twin and Family Research (MCTFR) undertook a genome-wide association study, which we describe here. A total of 8,405 research participants, clustered in four-member families, have been successfully genotyped on 527,829 single nucleotide polymorphism (SNP) markers using Illumina's Human660W-Quad array. Quality control screening of samples and markers as well as SNP imputation procedures are described. We also describe methods for ancestry control and how the familial clustering of the MCTFR sample can be accounted for in the analysis using a Rapid Feasible Generalized Least Squares algorithm. The rich longitudinal MCTFR assessments provide numerous opportunities for collaboration.

Original language	English (US)
Pages (from-to)	767-774
Number of pages	8
Journal	Twin Research and Human Genetics
Volume	15
Issue number	6
DOIs	https://doi.org/10.1017/thg.2012.62
State	Published - Dec 2012

Keywords

GWAS
Minnesota Center for Twin and Family Research
rapid feasible generalized least squares

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology
Genetics(clinical)

Access to Document

10.1017/thg.2012.62

Cite this

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AU - Oetting, William S.

AU - Schork, Nicholas

AU - Sul, Jae Hoon

AU - Iacono, William G.

AU - Mc Gue, Matt

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The minnesota center for twin and family research genome-wide association study

Abstract

Keywords

ASJC Scopus subject areas

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