The minnesota center for twin and family research genome-wide association study

Michael B. Miller, Saonli Basu, Julie Cunningham, Eleazar Eskin, Steven M. Malone, William S. Oetting, Nicholas Schork, Jae Hoon Sul, William G. Iacono, Matt Mc Gue

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

As part of the Genes, Environment and Development Initiative, the Minnesota Center for Twin and Family Research (MCTFR) undertook a genome-wide association study, which we describe here. A total of 8,405 research participants, clustered in four-member families, have been successfully genotyped on 527,829 single nucleotide polymorphism (SNP) markers using Illumina's Human660W-Quad array. Quality control screening of samples and markers as well as SNP imputation procedures are described. We also describe methods for ancestry control and how the familial clustering of the MCTFR sample can be accounted for in the analysis using a Rapid Feasible Generalized Least Squares algorithm. The rich longitudinal MCTFR assessments provide numerous opportunities for collaboration.

Original languageEnglish (US)
Pages (from-to)767-774
Number of pages8
JournalTwin Research and Human Genetics
Volume15
Issue number6
DOIs
StatePublished - Dec 2012

Keywords

  • GWAS
  • Minnesota Center for Twin and Family Research
  • rapid feasible generalized least squares

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology
  • Genetics(clinical)

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    Miller, M. B., Basu, S., Cunningham, J., Eskin, E., Malone, S. M., Oetting, W. S., Schork, N., Sul, J. H., Iacono, W. G., & Mc Gue, M. (2012). The minnesota center for twin and family research genome-wide association study. Twin Research and Human Genetics, 15(6), 767-774. https://doi.org/10.1017/thg.2012.62