The MIDA Mortality Risk Score: Development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation

Francesco Grigioni, Marie Annick Clavel, Jean Louis Vanoverschelde, Christophe Tribouilloy, Rodolfo Pizarro, Marianne Huebner, Jean Francois Avierinos, Andrea Barbieri, Rakesh Suri, Agnds Pasquet, Dan Rusinaru, Gaetano D. Gargiulo, Pablo Oberti, Alexis Thdron, Francesca Bursi, Hector I Michelena, Siham Lazam, Catherine Szymanski, Vuyisile T Nkomo, Martin SchumacherLetizia Bacchi-Reggiani, Maurice E Sarano

Research output: Contribution to journalArticle

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Abstract

Aims In degenerative mitral regurgitation (DMR), lack of mortality scores predicting death favours misperception of individual patients' risk and inappropriate decision-making. Methods and results The Mitral Regurgitation International Database (MIDA) registries include 3666 patients (age 66 ± 14 years; 70% males; follow-up 7.8 ± 5.0 years) with pure, isolated, DMR consecutively diagnosed by echocardiography at tertiary (European/North/South-American) centres. The MIDA Score was derived from the MIDA-Flail-Registry (2472 patients with DMR and flail leaflet-Derivation Cohort) by weighting all guideline-provided prognostic markers, and externally validated in the MIDA-BNP-Registry (1194 patients with DMR and flail leaflet/prolapse-Validation Cohort). The MIDA Score ranged from 0 to 12 depending on accumulating risk factors. In predicting total mortality post-diagnosis, the MIDA Score showed excellent concordance both in Derivation Cohort (c = 0.78) and Validation Cohort (c = 0.81). In the whole MIDA population (n = 3666 patients), 1-year mortality with Scores 0, 7-8, and 11-12 was 0.4, 17, and 48% under medical management and 1, 7, and 14% after surgery, respectively (P < 0.001). Five-year survival with Scores 0, 7-8, and 11-12 was 98 ± 1, 57 ± 4, and 21 ± 10% under medical management and 99 ± 1, 82 ± 2, and 57 ± 9% after surgery (P < 0.001). In models including all guideline-provided prognostic markers and the EuroScoreII, the MIDA Score provided incremental prognostic information (P < 0.002). Conclusion The MIDA Score may represent an innovative tool for DMR management, being able to position a given patient within a continuous spectrum of short- and long-term mortality risk, either under medical or surgical management. This innovative prognostic indicator may provide a specific framework for future clinical trials aiming to compare new technologies for DMR treatment in homogeneous risk categories of patients.

Original languageEnglish (US)
Pages (from-to)1281-1291
Number of pages11
JournalEuropean Heart Journal
Volume39
Issue number15
DOIs
StatePublished - Apr 14 2018

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Mitral Valve Insufficiency
Databases
Mortality
Registries
Guidelines
Prolapse
Echocardiography
Decision Making

Keywords

  • Mitral regurgitation
  • Mitral repair
  • Percutaneous mitral repair
  • Percutaneous mitral replacement
  • Prognosis
  • Surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The MIDA Mortality Risk Score : Development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation. / Grigioni, Francesco; Clavel, Marie Annick; Vanoverschelde, Jean Louis; Tribouilloy, Christophe; Pizarro, Rodolfo; Huebner, Marianne; Avierinos, Jean Francois; Barbieri, Andrea; Suri, Rakesh; Pasquet, Agnds; Rusinaru, Dan; Gargiulo, Gaetano D.; Oberti, Pablo; Thdron, Alexis; Bursi, Francesca; Michelena, Hector I; Lazam, Siham; Szymanski, Catherine; Nkomo, Vuyisile T; Schumacher, Martin; Bacchi-Reggiani, Letizia; Sarano, Maurice E.

In: European Heart Journal, Vol. 39, No. 15, 14.04.2018, p. 1281-1291.

Research output: Contribution to journalArticle

Grigioni, F, Clavel, MA, Vanoverschelde, JL, Tribouilloy, C, Pizarro, R, Huebner, M, Avierinos, JF, Barbieri, A, Suri, R, Pasquet, A, Rusinaru, D, Gargiulo, GD, Oberti, P, Thdron, A, Bursi, F, Michelena, HI, Lazam, S, Szymanski, C, Nkomo, VT, Schumacher, M, Bacchi-Reggiani, L & Sarano, ME 2018, 'The MIDA Mortality Risk Score: Development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation', European Heart Journal, vol. 39, no. 15, pp. 1281-1291. https://doi.org/10.1093/eurheartj/ehx465
Grigioni, Francesco ; Clavel, Marie Annick ; Vanoverschelde, Jean Louis ; Tribouilloy, Christophe ; Pizarro, Rodolfo ; Huebner, Marianne ; Avierinos, Jean Francois ; Barbieri, Andrea ; Suri, Rakesh ; Pasquet, Agnds ; Rusinaru, Dan ; Gargiulo, Gaetano D. ; Oberti, Pablo ; Thdron, Alexis ; Bursi, Francesca ; Michelena, Hector I ; Lazam, Siham ; Szymanski, Catherine ; Nkomo, Vuyisile T ; Schumacher, Martin ; Bacchi-Reggiani, Letizia ; Sarano, Maurice E. / The MIDA Mortality Risk Score : Development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation. In: European Heart Journal. 2018 ; Vol. 39, No. 15. pp. 1281-1291.
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abstract = "Aims In degenerative mitral regurgitation (DMR), lack of mortality scores predicting death favours misperception of individual patients' risk and inappropriate decision-making. Methods and results The Mitral Regurgitation International Database (MIDA) registries include 3666 patients (age 66 ± 14 years; 70{\%} males; follow-up 7.8 ± 5.0 years) with pure, isolated, DMR consecutively diagnosed by echocardiography at tertiary (European/North/South-American) centres. The MIDA Score was derived from the MIDA-Flail-Registry (2472 patients with DMR and flail leaflet-Derivation Cohort) by weighting all guideline-provided prognostic markers, and externally validated in the MIDA-BNP-Registry (1194 patients with DMR and flail leaflet/prolapse-Validation Cohort). The MIDA Score ranged from 0 to 12 depending on accumulating risk factors. In predicting total mortality post-diagnosis, the MIDA Score showed excellent concordance both in Derivation Cohort (c = 0.78) and Validation Cohort (c = 0.81). In the whole MIDA population (n = 3666 patients), 1-year mortality with Scores 0, 7-8, and 11-12 was 0.4, 17, and 48{\%} under medical management and 1, 7, and 14{\%} after surgery, respectively (P < 0.001). Five-year survival with Scores 0, 7-8, and 11-12 was 98 ± 1, 57 ± 4, and 21 ± 10{\%} under medical management and 99 ± 1, 82 ± 2, and 57 ± 9{\%} after surgery (P < 0.001). In models including all guideline-provided prognostic markers and the EuroScoreII, the MIDA Score provided incremental prognostic information (P < 0.002). Conclusion The MIDA Score may represent an innovative tool for DMR management, being able to position a given patient within a continuous spectrum of short- and long-term mortality risk, either under medical or surgical management. This innovative prognostic indicator may provide a specific framework for future clinical trials aiming to compare new technologies for DMR treatment in homogeneous risk categories of patients.",
keywords = "Mitral regurgitation, Mitral repair, Percutaneous mitral repair, Percutaneous mitral replacement, Prognosis, Surgery",
author = "Francesco Grigioni and Clavel, {Marie Annick} and Vanoverschelde, {Jean Louis} and Christophe Tribouilloy and Rodolfo Pizarro and Marianne Huebner and Avierinos, {Jean Francois} and Andrea Barbieri and Rakesh Suri and Agnds Pasquet and Dan Rusinaru and Gargiulo, {Gaetano D.} and Pablo Oberti and Alexis Thdron and Francesca Bursi and Michelena, {Hector I} and Siham Lazam and Catherine Szymanski and Nkomo, {Vuyisile T} and Martin Schumacher and Letizia Bacchi-Reggiani and Sarano, {Maurice E}",
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TY - JOUR

T1 - The MIDA Mortality Risk Score

T2 - Development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation

AU - Grigioni, Francesco

AU - Clavel, Marie Annick

AU - Vanoverschelde, Jean Louis

AU - Tribouilloy, Christophe

AU - Pizarro, Rodolfo

AU - Huebner, Marianne

AU - Avierinos, Jean Francois

AU - Barbieri, Andrea

AU - Suri, Rakesh

AU - Pasquet, Agnds

AU - Rusinaru, Dan

AU - Gargiulo, Gaetano D.

AU - Oberti, Pablo

AU - Thdron, Alexis

AU - Bursi, Francesca

AU - Michelena, Hector I

AU - Lazam, Siham

AU - Szymanski, Catherine

AU - Nkomo, Vuyisile T

AU - Schumacher, Martin

AU - Bacchi-Reggiani, Letizia

AU - Sarano, Maurice E

PY - 2018/4/14

Y1 - 2018/4/14

N2 - Aims In degenerative mitral regurgitation (DMR), lack of mortality scores predicting death favours misperception of individual patients' risk and inappropriate decision-making. Methods and results The Mitral Regurgitation International Database (MIDA) registries include 3666 patients (age 66 ± 14 years; 70% males; follow-up 7.8 ± 5.0 years) with pure, isolated, DMR consecutively diagnosed by echocardiography at tertiary (European/North/South-American) centres. The MIDA Score was derived from the MIDA-Flail-Registry (2472 patients with DMR and flail leaflet-Derivation Cohort) by weighting all guideline-provided prognostic markers, and externally validated in the MIDA-BNP-Registry (1194 patients with DMR and flail leaflet/prolapse-Validation Cohort). The MIDA Score ranged from 0 to 12 depending on accumulating risk factors. In predicting total mortality post-diagnosis, the MIDA Score showed excellent concordance both in Derivation Cohort (c = 0.78) and Validation Cohort (c = 0.81). In the whole MIDA population (n = 3666 patients), 1-year mortality with Scores 0, 7-8, and 11-12 was 0.4, 17, and 48% under medical management and 1, 7, and 14% after surgery, respectively (P < 0.001). Five-year survival with Scores 0, 7-8, and 11-12 was 98 ± 1, 57 ± 4, and 21 ± 10% under medical management and 99 ± 1, 82 ± 2, and 57 ± 9% after surgery (P < 0.001). In models including all guideline-provided prognostic markers and the EuroScoreII, the MIDA Score provided incremental prognostic information (P < 0.002). Conclusion The MIDA Score may represent an innovative tool for DMR management, being able to position a given patient within a continuous spectrum of short- and long-term mortality risk, either under medical or surgical management. This innovative prognostic indicator may provide a specific framework for future clinical trials aiming to compare new technologies for DMR treatment in homogeneous risk categories of patients.

AB - Aims In degenerative mitral regurgitation (DMR), lack of mortality scores predicting death favours misperception of individual patients' risk and inappropriate decision-making. Methods and results The Mitral Regurgitation International Database (MIDA) registries include 3666 patients (age 66 ± 14 years; 70% males; follow-up 7.8 ± 5.0 years) with pure, isolated, DMR consecutively diagnosed by echocardiography at tertiary (European/North/South-American) centres. The MIDA Score was derived from the MIDA-Flail-Registry (2472 patients with DMR and flail leaflet-Derivation Cohort) by weighting all guideline-provided prognostic markers, and externally validated in the MIDA-BNP-Registry (1194 patients with DMR and flail leaflet/prolapse-Validation Cohort). The MIDA Score ranged from 0 to 12 depending on accumulating risk factors. In predicting total mortality post-diagnosis, the MIDA Score showed excellent concordance both in Derivation Cohort (c = 0.78) and Validation Cohort (c = 0.81). In the whole MIDA population (n = 3666 patients), 1-year mortality with Scores 0, 7-8, and 11-12 was 0.4, 17, and 48% under medical management and 1, 7, and 14% after surgery, respectively (P < 0.001). Five-year survival with Scores 0, 7-8, and 11-12 was 98 ± 1, 57 ± 4, and 21 ± 10% under medical management and 99 ± 1, 82 ± 2, and 57 ± 9% after surgery (P < 0.001). In models including all guideline-provided prognostic markers and the EuroScoreII, the MIDA Score provided incremental prognostic information (P < 0.002). Conclusion The MIDA Score may represent an innovative tool for DMR management, being able to position a given patient within a continuous spectrum of short- and long-term mortality risk, either under medical or surgical management. This innovative prognostic indicator may provide a specific framework for future clinical trials aiming to compare new technologies for DMR treatment in homogeneous risk categories of patients.

KW - Mitral regurgitation

KW - Mitral repair

KW - Percutaneous mitral repair

KW - Percutaneous mitral replacement

KW - Prognosis

KW - Surgery

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